Stem-cell dynamics and lineage topology from in vivo fate mapping in the hematopoietic system
In recent years, sophisticated fate-mapping tools have been developed to study the behavior of stem cells in the intact organism. These experimental approaches are beginning to yield a quantitative picture of how cell numbers are regulated during steady state and in response to challenges. Focusing...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
20th April 2016
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| In: |
Current opinion in biotechnology
Year: 2016, Volume: 39, Pages: 150-156 |
| ISSN: | 1879-0429 |
| DOI: | 10.1016/j.copbio.2016.04.001 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.copbio.2016.04.001 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0958166916301094 
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| Author Notes: | Thomas Höfer, Melania Barile, Michael Flossdorf |
| Summary: | In recent years, sophisticated fate-mapping tools have been developed to study the behavior of stem cells in the intact organism. These experimental approaches are beginning to yield a quantitative picture of how cell numbers are regulated during steady state and in response to challenges. Focusing on hematopoiesis and immune responses, we discuss how novel mathematical approaches driven by these fate-mapping data have provided insights into the dynamics and topology of cellular differentiation pathways in vivo. The combination of experiment and theory has allowed to quantify the degree of self-renewal in stem and progenitor cells, shown how native hematopoiesis differs fundamentally from post-transplantation hematopoiesis, and uncovered that the diversification of T lymphocytes during immune responses resembles tissue renewal driven by stem cells. |
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| Item Description: | Gesehen am 19.05.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1879-0429 |
| DOI: | 10.1016/j.copbio.2016.04.001 |