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Tuning the cell adhesion on biofunctionalized nanoporous organic frameworks

The ability to control the structure and surface chemistry of biomaterials on a molecular level is crucial for optimizing their performance. Here, a novel type of nanoporous organic framework that is suited for the fabrication of thin films is described. These surface-grafted gels (SURGELs) are prep...

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Main Authors: Schmitt, Sophia Katharina (Author) , Hümmer, Julia (Author) , Kraus, Saskia (Author) , Welle, Alexander (Author) , Grosjean, Sylvain (Author) , Hanke, Maximilian (Author) , Rosenhahn, Axel (Author) , Bräse, Stefan (Author) , Wöll, Christof (Author) , Lee‐Thedieck, Cornelia (Author) , Tsotsalas, Manuel (Author)
Format: Article (Journal)
Language:English
Published: October 10, 2016
In: Advanced functional materials
Year: 2016, Volume: 26, Issue: 46, Pages: 8455-8462
ISSN:1616-3028
DOI:10.1002/adfm.201603054
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1002/adfm.201603054
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.201603054
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Author Notes:Sophia Schmitt, Julia Hümmer, Saskia Kraus, Alexander Welle, Sylvain Grosjean, Maximilian Hanke‐Roos, Axel Rosenhahn, Stefan Bräse, Christof Wöll, Cornelia Lee‐Thedieck, and Manuel Tsotsalas
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Summary:The ability to control the structure and surface chemistry of biomaterials on a molecular level is crucial for optimizing their performance. Here, a novel type of nanoporous organic framework that is suited for the fabrication of thin films is described. These surface-grafted gels (SURGELs) are prepared and functionalized using two orthogonal, metal-free click chemistries. The SURGELs are shown to be cytocompatible and to efficiently mediate adhesion of osteoblast-like cells. This process can be further enhanced by surface modification. In addition, the use of light-triggered reactions in combination with photomasks allows a patterned functionalization of the substrates. The potential to vary and exactly adjust the parameters within the SURGEL polymer network (including porosity and exact network topology on the nanometer scale as well as addressable functional groups) combined with the ability to functionalize their surfaces with any clickable biomolecule of choice in any desired pattern allow the targeted design of novel SURGEL-based biomaterials for applications in nanomedicine, tissue engineering scaffolds, wound dressing,and medical implants.
Item Description:Gesehen am 19.05.2020
Physical Description:Online Resource
ISSN:1616-3028
DOI:10.1002/adfm.201603054

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