Tuning the cell adhesion on biofunctionalized nanoporous organic frameworks
The ability to control the structure and surface chemistry of biomaterials on a molecular level is crucial for optimizing their performance. Here, a novel type of nanoporous organic framework that is suited for the fabrication of thin films is described. These surface-grafted gels (SURGELs) are prep...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
October 10, 2016
|
| In: |
Advanced functional materials
Year: 2016, Jahrgang: 26, Heft: 46, Pages: 8455-8462 |
| ISSN: | 1616-3028 |
| DOI: | 10.1002/adfm.201603054 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1002/adfm.201603054 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.201603054 
|
| Verfasserangaben: | Sophia Schmitt, Julia Hümmer, Saskia Kraus, Alexander Welle, Sylvain Grosjean, Maximilian Hanke‐Roos, Axel Rosenhahn, Stefan Bräse, Christof Wöll, Cornelia Lee‐Thedieck, and Manuel Tsotsalas |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1698541104 | ||
| 003 | DE-627 | ||
| 005 | 20230427091706.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200519s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/adfm.201603054 |2 doi | |
| 035 | |a (DE-627)1698541104 | ||
| 035 | |a (DE-599)KXP1698541104 | ||
| 035 | |a (OCoLC)1341325870 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Schmitt, Sophia Katharina |e VerfasserIn |0 (DE-588)1096522721 |0 (DE-627)856917958 |0 (DE-576)468073663 |4 aut | |
| 245 | 1 | 0 | |a Tuning the cell adhesion on biofunctionalized nanoporous organic frameworks |c Sophia Schmitt, Julia Hümmer, Saskia Kraus, Alexander Welle, Sylvain Grosjean, Maximilian Hanke‐Roos, Axel Rosenhahn, Stefan Bräse, Christof Wöll, Cornelia Lee‐Thedieck, and Manuel Tsotsalas |
| 264 | 1 | |c October 10, 2016 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 19.05.2020 | ||
| 520 | |a The ability to control the structure and surface chemistry of biomaterials on a molecular level is crucial for optimizing their performance. Here, a novel type of nanoporous organic framework that is suited for the fabrication of thin films is described. These surface-grafted gels (SURGELs) are prepared and functionalized using two orthogonal, metal-free click chemistries. The SURGELs are shown to be cytocompatible and to efficiently mediate adhesion of osteoblast-like cells. This process can be further enhanced by surface modification. In addition, the use of light-triggered reactions in combination with photomasks allows a patterned functionalization of the substrates. The potential to vary and exactly adjust the parameters within the SURGEL polymer network (including porosity and exact network topology on the nanometer scale as well as addressable functional groups) combined with the ability to functionalize their surfaces with any clickable biomolecule of choice in any desired pattern allow the targeted design of novel SURGEL-based biomaterials for applications in nanomedicine, tissue engineering scaffolds, wound dressing,and medical implants. | ||
| 650 | 4 | |a biofunctionalization | |
| 650 | 4 | |a click chemistry | |
| 650 | 4 | |a ideal network polymers | |
| 650 | 4 | |a metal-organic frameworks | |
| 650 | 4 | |a thin films | |
| 700 | 1 | |a Hümmer, Julia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kraus, Saskia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Welle, Alexander |e VerfasserIn |4 aut | |
| 700 | 1 | |a Grosjean, Sylvain |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hanke, Maximilian |e VerfasserIn |0 (DE-588)1059731002 |0 (DE-627)798792817 |0 (DE-576)415796687 |4 aut | |
| 700 | 1 | |a Rosenhahn, Axel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bräse, Stefan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wöll, Christof |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lee‐Thedieck, Cornelia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Tsotsalas, Manuel |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Advanced functional materials |d Weinheim : Wiley-VCH, 2001 |g 26(2016), 46, Seite 8455-8462 |h Online-Ressource |w (DE-627)32570063X |w (DE-600)2039420-2 |w (DE-576)094142440 |x 1616-3028 |7 nnas |a Tuning the cell adhesion on biofunctionalized nanoporous organic frameworks |
| 773 | 1 | 8 | |g volume:26 |g year:2016 |g number:46 |g pages:8455-8462 |g extent:8 |a Tuning the cell adhesion on biofunctionalized nanoporous organic frameworks |
| 856 | 4 | 0 | |u https://doi.org/10.1002/adfm.201603054 |x Resolving-System |x Verlag |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.201603054 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200519 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 1059731002 |a Hanke, Maximilian |m 1059731002:Hanke, Maximilian |d 910000 |d 910100 |e 910000PH1059731002 |e 910100PH1059731002 |k 0/910000/ |k 1/910000/910100/ |p 6 | ||
| 999 | |a KXP-PPN1698541104 |e 3668561990 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"8 S."}],"relHost":[{"part":{"year":"2016","pages":"8455-8462","issue":"46","volume":"26","text":"26(2016), 46, Seite 8455-8462","extent":"8"},"pubHistory":["11.2001 -"],"language":["eng"],"recId":"32570063X","disp":"Tuning the cell adhesion on biofunctionalized nanoporous organic frameworksAdvanced functional materials","note":["Gesehen am 10.11.2022","Ab 2022 Fortsetzung der Druck-Ausgabe"],"type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"title":"Advanced functional materials","title_sort":"Advanced functional materials"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["2039420-2"],"doi":["10.1002/(ISSN)1616-3028"],"eki":["32570063X"],"issn":["1616-3028"]},"origin":[{"publisherPlace":"Weinheim","dateIssuedDisp":"[2001]-","publisher":"Wiley-VCH"}]}],"name":{"displayForm":["Sophia Schmitt, Julia Hümmer, Saskia Kraus, Alexander Welle, Sylvain Grosjean, Maximilian Hanke‐Roos, Axel Rosenhahn, Stefan Bräse, Christof Wöll, Cornelia Lee‐Thedieck, and Manuel Tsotsalas"]},"origin":[{"dateIssuedKey":"2016","dateIssuedDisp":"October 10, 2016"}],"id":{"doi":["10.1002/adfm.201603054"],"eki":["1698541104"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 19.05.2020"],"language":["eng"],"recId":"1698541104","person":[{"roleDisplay":"VerfasserIn","display":"Schmitt, Sophia Katharina","role":"aut","family":"Schmitt","given":"Sophia Katharina"},{"roleDisplay":"VerfasserIn","display":"Hümmer, Julia","role":"aut","family":"Hümmer","given":"Julia"},{"given":"Saskia","family":"Kraus","role":"aut","roleDisplay":"VerfasserIn","display":"Kraus, Saskia"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Welle, Alexander","given":"Alexander","family":"Welle"},{"family":"Grosjean","given":"Sylvain","display":"Grosjean, Sylvain","roleDisplay":"VerfasserIn","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Hanke, Maximilian","role":"aut","family":"Hanke","given":"Maximilian"},{"role":"aut","display":"Rosenhahn, Axel","roleDisplay":"VerfasserIn","given":"Axel","family":"Rosenhahn"},{"family":"Bräse","given":"Stefan","roleDisplay":"VerfasserIn","display":"Bräse, Stefan","role":"aut"},{"role":"aut","display":"Wöll, Christof","roleDisplay":"VerfasserIn","given":"Christof","family":"Wöll"},{"family":"Lee‐Thedieck","given":"Cornelia","roleDisplay":"VerfasserIn","display":"Lee‐Thedieck, Cornelia","role":"aut"},{"family":"Tsotsalas","given":"Manuel","roleDisplay":"VerfasserIn","display":"Tsotsalas, Manuel","role":"aut"}],"title":[{"title_sort":"Tuning the cell adhesion on biofunctionalized nanoporous organic frameworks","title":"Tuning the cell adhesion on biofunctionalized nanoporous organic frameworks"}]} | ||
| SRT | |a SCHMITTSOPTUNINGTHEC1020 | ||