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Stimulation of central α2 receptors attenuates experimental necrotizing pancreatitis

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Severe necrotizing pancreatitis (SNP) is a disease with relevant morbidity and mortality until today. No specific therapy is in sight. Central α2 agonists such as clonidine and dexmedetomidine are known to have anti-inflammatory effects though the cholinergic anti-inflammatory pathway and are implem...

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Main Authors: Schneider, Lutz (Author) , Jabrailova, Bahar (Author) , Salem, Mohamed (Author) , Kilk, Karl Michael (Author) , Hofer, Stefan (Author) , Brenner, Thorsten (Author) , Strobel, Oliver (Author) , Hackert, Thilo (Author) , Werner, Jens (Author)
Format: Article (Journal)
Language:English
Published: February 2016
In: Pancreas
Year: 2016, Volume: 45, Issue: 2, Pages: 260-264
ISSN:1536-4828
DOI:10.1097/MPA.0000000000000474
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1097/MPA.0000000000000474
Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/pancreasjournal/Fulltext/2016/02000/Stimulation_of_Central__2_Receptors_Attenuates.15.aspx
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Author Notes:Lutz Schneider, Bahar Jabrailova, Mohammed Salem, Karl Kilk, Stefan Hofer, Thorsten Brenner, Oliver Strobel, Thilo Hackert, and Jens Werner
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Summary:Severe necrotizing pancreatitis (SNP) is a disease with relevant morbidity and mortality until today. No specific therapy is in sight. Central α2 agonists such as clonidine and dexmedetomidine are known to have anti-inflammatory effects though the cholinergic anti-inflammatory pathway and are implemented in the clinical routine as adjunct sedative drugs. Their potential effect on SNP has not yet been tested.
Item Description:Gesehen am 20.05.2020
Physical Description:Online Resource
ISSN:1536-4828
DOI:10.1097/MPA.0000000000000474

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