Human leucocyte antigen class I in hormone receptor-positive, HER2-negative breast cancer: association with response and survival after neoadjuvant chemotherapy

Clinical application of cancer immunotherapy requires a better understanding of tumor immunogenicity and the tumor microenvironment. HLA class I molecules present antigens to CD8+ cytotoxic cells. Their loss or downregulation is frequently found in tumors resulting in reduced T cell responses and wo...

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Main Authors:	Sinn, Bruno (Author) , Weber, Karsten E. (Author) , Schmitt, Wolfgang Daniel (Author) , Fasching, Peter Andreas (Author) , Symmans, William Fraser (Author) , Blohmer, Jens-Uwe (Author) , Karn, Thomas (Author) , Taube, Eliane Tabea (Author) , Klauschen, Frederick (Author) , Marmé, Frederik (Author) , Schem, Christian (Author) , Stickeler, Elmar (Author) , Ataseven, Beyhan (Author) , Huober, Jens (Author) , Minckwitz, Gunter von (Author) , Seliger, Barbara (Author) , Denkert, Carsten (Author) , Loibl, Sibylle (Author)
Format:	Article (Journal)
Language:	English
Published:	11 December 2019
In:	Breast cancer research Year: 2019, Volume: 21, Pages: 1-9
ISSN:	1465-542X
DOI:	10.1186/s13058-019-1231-z
Online Access:	Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13058-019-1231-z
Author Notes:	Bruno Valentin Sinn, Karsten E. Weber, Wolfgang Daniel Schmitt, Peter A. Fasching, William Fraser Symmans, Jens-Uwe Blohmer, Thomas Karn, Eliane Tabea Taube, Frederick Klauschen, Frederik Marmé, Christian Schem, Elmar Stickeler, Beyhan Ataseven, Jens Huober, Gunter von Minckwitz, Barbara Seliger, Carsten Denkert, and Sibylle Loibl