Mechanosensing is critical for axon growth in the developing brain
Much of what is known about nervous system development is based on chemical signaling. In this study, Koser et al. demonstrate that developing neurons also respond to mechanical signals and that local tissue stiffness is a regulator of neuronal growth in vivo.
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
19 September 2016
|
| In: |
Nature neuroscience
Year: 2016, Jahrgang: 19, Heft: 12, Pages: 1592-1598 |
| ISSN: | 1546-1726 |
| DOI: | 10.1038/nn.4394 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nn.4394 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nn.4394 |
| Verfasserangaben: | David E. Koser, Amelia J. Thompson, Sarah K. Foster, Asha Dwivedy, Eva K. Pillai, Graham K. Sheridan, Hanno Svoboda, Matheus Viana, Luciano da F. Costa, Jochen Guck, Christine E. Holt & Kristian Franze |
| Zusammenfassung: | Much of what is known about nervous system development is based on chemical signaling. In this study, Koser et al. demonstrate that developing neurons also respond to mechanical signals and that local tissue stiffness is a regulator of neuronal growth in vivo. |
|---|---|
| Beschreibung: | Gesehen am 20.05.2020 |
| Beschreibung: | Online Resource |
| ISSN: | 1546-1726 |
| DOI: | 10.1038/nn.4394 |