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Mechanosensing is critical for axon growth in the developing brain

Much of what is known about nervous system development is based on chemical signaling. In this study, Koser et al. demonstrate that developing neurons also respond to mechanical signals and that local tissue stiffness is a regulator of neuronal growth in vivo.

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Bibliographic Details
Main Authors: Koser, David E. (Author) , Thompson, Amelia J. (Author) , Foster, Sarah K. (Author) , Dwivedy, Asha (Author) , Pillai, Eva K. (Author) , Sheridan, Graham K. (Author) , Svoboda, Hanno (Author) , Viana, Matheus (Author) , Costa, Luciano da F. (Author) , Guck, Jochen (Author) , Holt, Christine E. (Author) , Franze, Kristian (Author)
Format: Article (Journal)
Language:English
Published: 19 September 2016
In: Nature neuroscience
Year: 2016, Volume: 19, Issue: 12, Pages: 1592-1598
ISSN:1546-1726
DOI:10.1038/nn.4394
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nn.4394
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nn.4394
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Author Notes:David E. Koser, Amelia J. Thompson, Sarah K. Foster, Asha Dwivedy, Eva K. Pillai, Graham K. Sheridan, Hanno Svoboda, Matheus Viana, Luciano da F. Costa, Jochen Guck, Christine E. Holt & Kristian Franze
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Summary:Much of what is known about nervous system development is based on chemical signaling. In this study, Koser et al. demonstrate that developing neurons also respond to mechanical signals and that local tissue stiffness is a regulator of neuronal growth in vivo.
Item Description:Gesehen am 20.05.2020
Physical Description:Online Resource
ISSN:1546-1726
DOI:10.1038/nn.4394

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