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Circulating tumor cells exhibit stem cell characteristics in an orthotopic mouse model of colorectal cancer

The prognosis of colorectal cancer (CRC) is closely linked to the occurrence of distant metastases, which putatively develop from circulating tumor cells (CTCs) shed into circulation by the tumor. As far more CTCs are shed than eventually metastases develop, only a small subfraction of CTCs harbor f...

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Main Authors: Schölch, Sebastian (Author) , García, Sebastián A. (Author) , Iwata, Naoki (Author) , Niemietz, Thomas (Author) , Betzler, Alexander M. (Author) , Nanduri, Lahiri K. (Author) , Bork, Ulrich (Author) , Kahlert, Christoph (Author) , Thepkaysone, May-Linn (Author) , Swiersy, Anka (Author) , Büchler, Markus W. (Author) , Reißfelder, Christoph (Author) , Weitz, Jürgen (Author) , Rahbari, Nuh Nabi (Author)
Format: Article (Journal)
Language:English
Published: March 25, 2016
In: OncoTarget
Year: 2016, Volume: 7, Issue: 19, Pages: 27232-27242
ISSN:1949-2553
DOI:10.18632/oncotarget.8373
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.18632/oncotarget.8373
Verlag, lizenzpflichtig, Volltext: https://www.oncotarget.com/article/8373/text/
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Author Notes:Sebastian Schölch, Sebastián A. García, Naoki Iwata, Thomas Niemietz, Alexander M. Betzler, Lahiri K. Nanduri, Ulrich Bork, Christoph Kahlert, May-Linn Thepkaysone, Anka Swiersy, Markus W. Büchler, Christoph Reissfelder, Jürgen Weitz, Nuh N. Rahbari
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Summary:The prognosis of colorectal cancer (CRC) is closely linked to the occurrence of distant metastases, which putatively develop from circulating tumor cells (CTCs) shed into circulation by the tumor. As far more CTCs are shed than eventually metastases develop, only a small subfraction of CTCs harbor full tumorigenic potential. The aim of this study was to further characterize CRC-derived CTCs to eventually identify the clinically relevant subfraction of CTCs.
Item Description:Gesehen am 20.05.2020
Physical Description:Online Resource
ISSN:1949-2553
DOI:10.18632/oncotarget.8373

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