Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation
During oxidative DNA demethylation, Neil DNA glycosylases stimulate processing of abasic sites generated by Tdg, which excises 5-methylcytosine oxidation products generated by Tet dioxygenases, promoting restoration of unmodified cytosines via base excision repair.
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
11 January 2016
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| In: |
Nature structural & molecular biology
Year: 2016, Jahrgang: 23, Heft: 2, Pages: 116-124 |
| ISSN: | 1545-9985 |
| DOI: | 10.1038/nsmb.3151 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1038/nsmb.3151 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nsmb.3151 |
| Verfasserangaben: | Lars Schomacher, Dandan Han, Michael U. Musheev, Khelifa Arab, Sabine Kienhöfer, Annika von Seggern & Christof Niehrs |
| Zusammenfassung: | During oxidative DNA demethylation, Neil DNA glycosylases stimulate processing of abasic sites generated by Tdg, which excises 5-methylcytosine oxidation products generated by Tet dioxygenases, promoting restoration of unmodified cytosines via base excision repair. |
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| Beschreibung: | Das PDF enthält zusätzlich einen Anhang von drei Seiten Gesehen am 20.05.2020 |
| Beschreibung: | Online Resource |
| ISSN: | 1545-9985 |
| DOI: | 10.1038/nsmb.3151 |