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Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation

During oxidative DNA demethylation, Neil DNA glycosylases stimulate processing of abasic sites generated by Tdg, which excises 5-methylcytosine oxidation products generated by Tet dioxygenases, promoting restoration of unmodified cytosines via base excision repair.

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Bibliographic Details
Main Authors: Schomacher, Lars (Author) , Han, Dandan (Author) , Musheev, Michael U. (Author) , Arab, Khelifa (Author) , Kienhöfer, Sabine (Author) , Seggern, Annika von (Author) , Niehrs, Christof (Author)
Format: Article (Journal)
Language:English
Published: 11 January 2016
In: Nature structural & molecular biology
Year: 2016, Volume: 23, Issue: 2, Pages: 116-124
ISSN:1545-9985
DOI:10.1038/nsmb.3151
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1038/nsmb.3151
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nsmb.3151
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Author Notes:Lars Schomacher, Dandan Han, Michael U. Musheev, Khelifa Arab, Sabine Kienhöfer, Annika von Seggern & Christof Niehrs
Description
Summary:During oxidative DNA demethylation, Neil DNA glycosylases stimulate processing of abasic sites generated by Tdg, which excises 5-methylcytosine oxidation products generated by Tet dioxygenases, promoting restoration of unmodified cytosines via base excision repair.
Item Description:Das PDF enthält zusätzlich einen Anhang von drei Seiten
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Physical Description:Online Resource
ISSN:1545-9985
DOI:10.1038/nsmb.3151

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