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Subretinal implantation of a monolayer of human embryonic stem cell-derived retinal pigment epithelium: a feasibility and safety study in Yucatán minipigs

A subretinal implant termed CPCB-RPE1 is currently being developed to surgically replace dystrophic RPE in patients with dry age-related macular degeneration (AMD) and severe vision loss. CPCB-RPE1 is composed of a terminally differentiated, polarized human embryonic stem cell-derived RPE (hESC-RPE)...

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Bibliographic Details
Main Author: Koss, Michael Janusz (Author)
Format: Article (Journal)
Language:English
Published: 22 June 2016
In: Graefe's archive for clinical and experimental ophthalmology
Year: 2016, Volume: 254, Issue: 8, Pages: 1553-1565
ISSN:1435-702X
DOI:10.1007/s00417-016-3386-y
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00417-016-3386-y
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Author Notes:Michael J. Koss, Paulo Falabella, Francisco R. Stefanini, Marcel Pfister, Biju B. Thomas, Amir H. Kashani, Rodrigo Brant, Danhong Zhu, Dennis O. Clegg, David R. Hinton, Mark S. Humayun
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Summary:A subretinal implant termed CPCB-RPE1 is currently being developed to surgically replace dystrophic RPE in patients with dry age-related macular degeneration (AMD) and severe vision loss. CPCB-RPE1 is composed of a terminally differentiated, polarized human embryonic stem cell-derived RPE (hESC-RPE) monolayer pre-grown on a biocompatible, mesh-supported submicron parylene C membrane. The objective of the present delivery study was to assess the feasibility and 1-month safety of CPCB-RPE1 implantation in Yucatán minipigs, whose eyes are similar to human eyes in size and gross retinal anatomy.
Item Description:Gesehen am 22.05.2020
Physical Description:Online Resource
ISSN:1435-702X
DOI:10.1007/s00417-016-3386-y

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