Subretinal implantation of a monolayer of human embryonic stem cell-derived retinal pigment epithelium: a feasibility and safety study in Yucatán minipigs
A subretinal implant termed CPCB-RPE1 is currently being developed to surgically replace dystrophic RPE in patients with dry age-related macular degeneration (AMD) and severe vision loss. CPCB-RPE1 is composed of a terminally differentiated, polarized human embryonic stem cell-derived RPE (hESC-RPE)...
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
22 June 2016
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| In: |
Graefe's archive for clinical and experimental ophthalmology
Year: 2016, Jahrgang: 254, Heft: 8, Pages: 1553-1565 |
| ISSN: | 1435-702X |
| DOI: | 10.1007/s00417-016-3386-y |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00417-016-3386-y
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| Verfasserangaben: | Michael J. Koss, Paulo Falabella, Francisco R. Stefanini, Marcel Pfister, Biju B. Thomas, Amir H. Kashani, Rodrigo Brant, Danhong Zhu, Dennis O. Clegg, David R. Hinton, Mark S. Humayun |
| Zusammenfassung: | A subretinal implant termed CPCB-RPE1 is currently being developed to surgically replace dystrophic RPE in patients with dry age-related macular degeneration (AMD) and severe vision loss. CPCB-RPE1 is composed of a terminally differentiated, polarized human embryonic stem cell-derived RPE (hESC-RPE) monolayer pre-grown on a biocompatible, mesh-supported submicron parylene C membrane. The objective of the present delivery study was to assess the feasibility and 1-month safety of CPCB-RPE1 implantation in Yucatán minipigs, whose eyes are similar to human eyes in size and gross retinal anatomy. |
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| Beschreibung: | Gesehen am 22.05.2020 |
| Beschreibung: | Online Resource |
| ISSN: | 1435-702X |
| DOI: | 10.1007/s00417-016-3386-y |