Sensitization to reactive diluents and hardeners in epoxy resin systems: IVDK data 2002-2011$dpart II: concomitant reactions
BACKGROUND: Beside the basic resins, reactive diluents and hardeners are important sensitizers in epoxy resin systems (ERSs). Because of chemical similarities, immunological cross-reactivity may occur. - OBJECTIVES: To analyse concomitant reactivity among reactive diluents and hardeners in the patie...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2016
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| In: |
Contact dermatitis
Year: 2015, Volume: 74, Issue: 2, Pages: 94-101 |
| ISSN: | 1600-0536 |
| DOI: | 10.1111/cod.12490 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/cod.12490 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/cod.12490 
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| Author Notes: | Johannes Geier, Holger Lessmann, Uwe Hillen, Christoph Skudlik and Uta Jappe |
| Summary: | BACKGROUND: Beside the basic resins, reactive diluents and hardeners are important sensitizers in epoxy resin systems (ERSs). Because of chemical similarities, immunological cross-reactivity may occur. - OBJECTIVES: To analyse concomitant reactivity among reactive diluents and hardeners in the patients concerned, as one integral part of a research project on the sensitizing capacity of ERSs (FP-0324). - METHODS: A retrospective analysis of data from the Information Network of Departments of Dermatology (IVDK), 2002-2011, was performed. - RESULTS: There was close concomitant reactivity to 1,6-hexanediol diglycidyl ether and 1,4-butanediol diglycidyl ether (1,4-BDDGE), and to phenyl glycidyl ether (PGE) and cresyl glycidyl ether (CGE), whereas reactions to p-tert-butylphenyl glycidyl ether occurred more independently from those to PGE and CGE. Concomitant reactions to butyl glycidyl ether and 1,4-BDDGE may point to a common allergenic compound derived from the metabolism of 1,4-BDDGE. Among the structurally more diverse group of hardeners, there was no evidence of immunological cross-reactions. - CONCLUSIONS: More detailed knowledge of cross-reactivity among ERS components facilitates the interpretation of patch test results and will allow safer ERSs to be composed in the future. |
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| Item Description: | Accepted for publication: 21 September 2015 Gesehen am 22.05.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1600-0536 |
| DOI: | 10.1111/cod.12490 |