Elevated hepcidin serum level in response to inflammatory and iron signals in exercising athletes is independent of moderate supplementation with vitamin C and E

Iron deficiency among endurance athletes is of major concern for coaches, physicians, and nutritionists. Recently, it has been observed that hepcidin, the master regulator of iron metabolism, was upregulated after exercise and was found to be related to interleukin-6 (IL-6) elevation. In this study...

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Main Authors: Díaz, Víctor (Author) , Peinado, Ana B. (Author) , Barba‐Moreno, Laura (Author) , Altamura, Sandro (Author) , Butragueño, Javier (Author) , González‐Gross, Marcela (Author) , Alteheld, Birgit (Author) , Stehle, Peter (Author) , Zapico, Augusto G. (Author) , Muckenthaler, Martina (Author) , Gassmann, Max (Author)
Format: Article (Journal)
Language:English
Published: 04 August 2015
In: Physiological reports
Year: 2015, Volume: 3, Issue: 8
ISSN:2051-817X
DOI:10.14814/phy2.12475
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.14814/phy2.12475
Verlag, lizenzpflichtig, Volltext: https://physoc.onlinelibrary.wiley.com/doi/abs/10.14814/phy2.12475
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Author Notes:Víctor Díaz, Ana B. Peinado, Laura Barba‐Moreno, Sandro Altamura, Javier Butragueño, Marcela González‐Gross, Birgit Alteheld, Peter Stehle, Augusto G. Zapico, Martina U. Muckenthaler & Max Gassmann
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Summary:Iron deficiency among endurance athletes is of major concern for coaches, physicians, and nutritionists. Recently, it has been observed that hepcidin, the master regulator of iron metabolism, was upregulated after exercise and was found to be related to interleukin-6 (IL-6) elevation. In this study performed on noniron deficient and well-trained runners, we observed that hepcidin concentrations remain elevated in response to inflammatory and iron signals despite a 28-days supplementation period with vitamins C (500 mg/day) and E (400 IU/day).
Item Description:Gesehen am 25.05.2020
Physical Description:Online Resource
ISSN:2051-817X
DOI:10.14814/phy2.12475