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Establishment of a patient-derived orthotopic osteosarcoma mouse model

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Osteosarcoma (OS) is the most common pediatric primary malignant bone tumor. As the prognosis for patients following standard treatment did not improve for almost three decades, functional preclinical models that closely reflect important clinical cancer characteristics are urgently needed to develo...

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Main Authors: Blattmann, Claudia (Author) , Thiemann, Markus (Author) , Stenzinger, Albrecht (Author) , Roth, Eva Kathrin (Author) , Dittmar, Anne (Author) , Witt, Hendrik (Author) , Lehner, Burkhard (Author) , Renker, Eva Kristin (Author) , Jugold, Manfred (Author) , Eichwald, Viktoria (Author) , Weichert, Wilko (Author) , Huber, Peter E. (Author) , Kulozik, Andreas (Author)
Format: Article (Journal)
Language:English
Published: 30 April 2015
In: Journal of translational medicine
Year: 2015, Volume: 13, Pages: 1-10
ISSN:1479-5876
DOI:10.1186/s12967-015-0497-x
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12967-015-0497-x
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Author Notes:Claudia Blattmann, Markus Thiemann, Albrecht Stenzinger, Eva K. Roth, Anne Dittmar, Hendrik Witt, Burkhard Lehner, Eva Renker, Manfred Jugold, Viktoria Eichwald, Wilko Weichert, Peter E. Huber and Andreas E. Kulozik
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Summary:Osteosarcoma (OS) is the most common pediatric primary malignant bone tumor. As the prognosis for patients following standard treatment did not improve for almost three decades, functional preclinical models that closely reflect important clinical cancer characteristics are urgently needed to develop and evaluate new treatment strategies. The objective of this study was to establish an orthotopic xenotransplanted mouse model using patient-derived tumor tissue.
Item Description:Gesehen am 26.05.2020
Physical Description:Online Resource
ISSN:1479-5876
DOI:10.1186/s12967-015-0497-x

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