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Renal cell carcinoma with inferior vena cava involvement: prognostic effect of tumor thrombus consistency on cancer specific survival

Background Renal cell carcinoma forming a venous tumor thrombus (VTT) in the inferior vena cava (IVC) has a poor prognosis. Recent investigations have been focused on prognostic markers of survival. Thrombus consistency (TC) has been proposed to be of significant value but yet there are conflicting...

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Main Authors: Mager, René (Author) , Daneshmand, Siamak (Author) , Evans, Christopher P. (Author) , Palou, Joan (Author) , Martínez‐Salamanca, Juan I. (Author) , Master, Viraj A. (Author) , McKiernan, James M. (Author) , Libertino, John A. (Author) , Haferkamp, Axel (Author) , Capitanio, Umberto (Author) , Carballido, Joaquín A. (Author) , Chantada, Venancio (Author) , Chromecki, Thomas (Author) , Ciancio, Gaetano (Author) , Gontero, Paolo (Author) , González, Javier (Author) , Hohenfellner, Markus (Author) , Huang, William C. (Author) , Koppie, Theresa M. (Author) , Espinós, Estefanía Linares (Author) , Lorentz, Adam (Author) , Montorsi, Francesco (Author) , Novara, Giacomo (Author) , O'Malley, Padraic (Author) , Pahernik, Sascha (Author) , Moreno, José Luis Pontones (Author) , Pruthi, Raj S. (Author) , Faba, Oscar Rodriguez (Author) , Russo, Paul (Author) , Scherr, Douglas S. (Author) , Shariat, Shahrokh F. (Author) , Spahn, Martin (Author) , Terrone, Carlo (Author) , Tilki, Derya (Author) , Vázquez‐Martul, Dario (Author) , Donoso, Cesar Vera (Author) , Vergho, Daniel (Author) , Wallen, Eric M. (Author) , Zigeuner, Richard (Author)
Format: Article (Journal)
Language:English
Published: 26 August 2016
In: Journal of surgical oncology
Year: 2016, Volume: 114, Issue: 6, Pages: 764-768
ISSN:1096-9098
DOI:10.1002/jso.24395
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/jso.24395
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/jso.24395
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Author Notes:Rene Mager, MD, Siamak Daneshmand, MD, Christopher P. Evans, MD, Joan Palou, MD, PhD, Juan I. Martínez‐Salamanca, MD; Viraj A. Master, MD, PhD, James M. McKiernan, MD, John A. Libertino, MD, Axel Haferkamp, MD, on behalf of the International Renal Cell Carcinoma-Venous Thrombus Consortium, Axel Haferkamp, Umberto Capitanio, Joaquín A. Carballido, Venancio Chantada, Thomas Chromecki, Gaetano Ciancio, Siamak Daneshmand, Christopher P. Evans, Paolo Gontero, Javier González, Markus Hohenfellner, William C. Huang, Theresa M. Koppie, John A. Libertino, Estefanía Linares Espinós, Adam Lorentz, Juan I. Martínez‐Salamanca, Viraj A. Master, James M. McKiernan, Francesco Montorsi, Giacomo Novara, Padraic O'Malley, Sascha Pahernik, Joan Palou, José Luis Pontones Moreno, Raj S. Pruthi, Oscar Rodriguez Faba, Paul Russo, Douglas S. Scherr, Shahrokh F. Shariat, Martin Spahn, Carlo Terrone, Derya Tilki, Dario Vázquez‐Martul, Cesar Vera Donoso, Daniel Vergho, Eric M. Wallen, and Richard Zigeuner
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Summary:Background Renal cell carcinoma forming a venous tumor thrombus (VTT) in the inferior vena cava (IVC) has a poor prognosis. Recent investigations have been focused on prognostic markers of survival. Thrombus consistency (TC) has been proposed to be of significant value but yet there are conflicting data. The aim of this study is to test the effect of IVC VTT consistency on cancer specific survival (CSS) in a multi-institutional cohort. Methods The records of 413 patients collected by the International Renal Cell Carcinoma-Venous Thrombus Consortium were retrospectively analyzed. All patients underwent radical nephrectomy and tumor thrombectomy. Kaplan-Meier estimate and Cox regression analyses investigated the impact of TC on CSS in addition to established clinicopathological predictors. Results VTT was solid in 225 patients and friable in 188 patients. Median CSS was 50 months in solid and 45 months in friable VTT. TC showed no significant association with metastatic spread, pT stage, perinephric fat invasion, and higher Fuhrman grade. Survival analysis and Cox regression rejected TC as prognostic marker for CSS. Conclusions In the largest cohort published so far, TC seems not to be independently associated with survival in RCC patients and should therefore not be included in risk stratification models. J. Surg. Oncol. 2016;114:764-768. © 2016 Wiley Periodicals, Inc.
Item Description:Gesehen am 26.05.2020
Physical Description:Online Resource
ISSN:1096-9098
DOI:10.1002/jso.24395

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