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Absent sleep EEG spindle activity in GluA1 (Gria1) knockout mice: relevance to neuropsychiatric disorders

Sleep EEG spindles have been implicated in attention, sensory processing, synaptic plasticity and memory consolidation. In humans, deficits in sleep spindles have been reported in a wide range of neurological and psychiatric disorders, including schizophrenia. Genome-wide association studies have su...

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Main Authors: Ang, Gauri (Author) , McKillop, Laura E. (Author) , Purple, Ross (Author) , Blanco-Duque, Cristina (Author) , Peirson, Stuart N. (Author) , Foster, Russell G. (Author) , Harrison, Paul J. (Author) , Sprengel, Rolf (Author) , Davies, Kay E. (Author) , Oliver, Peter L. (Author) , Bannerman, David M. (Author) , Vyazovskiy, Vladyslav V. (Author)
Format: Article (Journal)
Language:English
Published: 14 August 2018
In: Translational Psychiatry
Year: 2018, Volume: 8, Pages: 1-14
ISSN:2158-3188
DOI:10.1038/s41398-018-0199-2
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41398-018-0199-2
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41398-018-0199-2
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Author Notes:Gauri Ang, Laura E. McKillop, Ross Purple, Cristina Blanco-Duque, Stuart N. Peirson, Russell G. Foster, Paul J. Harrison, Rolf Sprengel, Kay E. Davies, Peter L. Oliver, David M. Bannerman and Vladyslav V. Vyazovskiy
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Summary:Sleep EEG spindles have been implicated in attention, sensory processing, synaptic plasticity and memory consolidation. In humans, deficits in sleep spindles have been reported in a wide range of neurological and psychiatric disorders, including schizophrenia. Genome-wide association studies have suggested a link between schizophrenia and genes associated with synaptic plasticity, including the Gria1 gene which codes for the GluA1 subunit of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. Gria1−/− mice exhibit a phenotype relevant for neuropsychiatric disorders, including reduced synaptic plasticity and, at the behavioural level, attentional deficits leading to aberrant salience. In this study we report a striking reduction of EEG power density including the spindle-frequency range (10-15 Hz) during sleep in Gria1−/− mice. The reduction of spindle-activity in Gria1−/− mice was accompanied by longer REM sleep episodes, increased EEG slow-wave activity in the occipital derivation during baseline sleep, and a reduced rate of decline of EEG slow wave activity (0.5-4 Hz) during NREM sleep after sleep deprivation. These data provide a novel link between glutamatergic dysfunction and sleep abnormalities in a schizophrenia-relevant mouse model.
Item Description:Gesehen am 26.05.2020
Physical Description:Online Resource
ISSN:2158-3188
DOI:10.1038/s41398-018-0199-2

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