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Absent sleep EEG spindle activity in GluA1 (Gria1) knockout mice: relevance to neuropsychiatric disorders

Sleep EEG spindles have been implicated in attention, sensory processing, synaptic plasticity and memory consolidation. In humans, deficits in sleep spindles have been reported in a wide range of neurological and psychiatric disorders, including schizophrenia. Genome-wide association studies have su...

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Hauptverfasser: Ang, Gauri (VerfasserIn) , McKillop, Laura E. (VerfasserIn) , Purple, Ross (VerfasserIn) , Blanco-Duque, Cristina (VerfasserIn) , Peirson, Stuart N. (VerfasserIn) , Foster, Russell G. (VerfasserIn) , Harrison, Paul J. (VerfasserIn) , Sprengel, Rolf (VerfasserIn) , Davies, Kay E. (VerfasserIn) , Oliver, Peter L. (VerfasserIn) , Bannerman, David M. (VerfasserIn) , Vyazovskiy, Vladyslav V. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 14 August 2018
In: Translational Psychiatry
Year: 2018, Jahrgang: 8, Pages: 1-14
ISSN:2158-3188
DOI:10.1038/s41398-018-0199-2
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41398-018-0199-2
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41398-018-0199-2
Volltext
Verfasserangaben:Gauri Ang, Laura E. McKillop, Ross Purple, Cristina Blanco-Duque, Stuart N. Peirson, Russell G. Foster, Paul J. Harrison, Rolf Sprengel, Kay E. Davies, Peter L. Oliver, David M. Bannerman and Vladyslav V. Vyazovskiy
Beschreibung
Zusammenfassung:Sleep EEG spindles have been implicated in attention, sensory processing, synaptic plasticity and memory consolidation. In humans, deficits in sleep spindles have been reported in a wide range of neurological and psychiatric disorders, including schizophrenia. Genome-wide association studies have suggested a link between schizophrenia and genes associated with synaptic plasticity, including the Gria1 gene which codes for the GluA1 subunit of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. Gria1−/− mice exhibit a phenotype relevant for neuropsychiatric disorders, including reduced synaptic plasticity and, at the behavioural level, attentional deficits leading to aberrant salience. In this study we report a striking reduction of EEG power density including the spindle-frequency range (10-15 Hz) during sleep in Gria1−/− mice. The reduction of spindle-activity in Gria1−/− mice was accompanied by longer REM sleep episodes, increased EEG slow-wave activity in the occipital derivation during baseline sleep, and a reduced rate of decline of EEG slow wave activity (0.5-4 Hz) during NREM sleep after sleep deprivation. These data provide a novel link between glutamatergic dysfunction and sleep abnormalities in a schizophrenia-relevant mouse model.
Beschreibung:Gesehen am 26.05.2020
Beschreibung:Online Resource
ISSN:2158-3188
DOI:10.1038/s41398-018-0199-2

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