Myc depletion induces a pluripotent dormant state mimicking diapause

Mouse embryonic stem cells (ESCs) are maintained in a naive ground state of pluripotency in the presence of MEK and GSK3 inhibitors. Here, we show that ground-state ESCs express low Myc levels.

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Bibliographic Details
Main Authors:	Scognamiglio, Roberta (Author) , Cabezas-Wallscheid, Nina (Author) , Thier, Marc Christian (Author) , Altamura, Sandro (Author) , Reyes, Alejandro (Author) , Prendergast, Áine M. (Author) , Baumgärtner, Daniel (Author) , Carnevalli, Larissa S. (Author) , Atzberger, Ann (Author) , Haas, Simon (Author) , von Paleske, Lisa (Author) , Boroviak, Thorsten (Author) , Wörsdörfer, Philipp (Author) , Essers, Marieke (Author) , Kloz, Ulrich (Author) , Eisenman, Robert N. (Author) , Edenhofer, Frank (Author) , Bertone, Paul (Author) , Huber, Wolfgang (Author) , van der Hoeven, Franciscus (Author) , Smith, Austin (Author) , Trumpp, Andreas (Author)
Format:	Article (Journal)
Language:	English
Published:	February 11, 2016
In:	Cell Year: 2016, Volume: 164, Issue: 4, Pages: 668-680
ISSN:	1097-4172
DOI:	10.1016/j.cell.2015.12.033
Online Access:	Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.cell.2015.12.033 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0092867415016979
Author Notes:	Roberta Scognamiglio, Nina Cabezas-Wallscheid, Marc Christian Thier, Sandro Altamura, Alejandro Reyes, Áine M. Prendergast, Daniel Baumgärtner, Larissa S. Carnevalli, Ann Atzberger, Simon Haas, Lisa von Paleske, Thorsten Boroviak, Philipp Wörsdörfer, Marieke A.G. Essers, Ulrich Kloz, Robert N. Eisenman, Frank Edenhofer, Paul Bertone, Wolfgang Huber, Franciscus van der Hoeven, Austin Smith, and Andreas Trumpp

Description
Summary:	Mouse embryonic stem cells (ESCs) are maintained in a naive ground state of pluripotency in the presence of MEK and GSK3 inhibitors. Here, we show that ground-state ESCs express low Myc levels.
Item Description:	Gesehen am 27.05.2020
Physical Description:	Online Resource
ISSN:	1097-4172
DOI:	10.1016/j.cell.2015.12.033