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Peripheral blood natural killer cell percentages in granulomatosis with polyangiitis correlate with disease inactivity and stage

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The role of CD3−CD56+ natural killer (NK) cells in granulomatosis with polyangiitis (GPA) is poorly understood. Recently, it has been shown that peripheral blood NK cells can kill renal microvascular endothelial cells, suggesting a pathogenic role of NK cells in this disease. So far, subset distribu...

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Main Authors: Merkt, Wolfgang (Author) , Lasitschka, Felix (Author) , Tretter, Theresa (Author) , Saure, Daniel (Author) , Hundemer, Michael (Author) , Schwenger, Vedat (Author) , Blank, Norbert (Author) , Lorenz, Hanns-Martin (Author)
Format: Article (Journal)
Language:English
Published: 21 November 2015
In: Arthritis Research & Therapy
Year: 2015, Volume: 17
ISSN:1465-9913
DOI:10.1186/s13075-015-0851-7
Online Access:Verlag, Volltext: https://doi.org/10.1186/s13075-015-0851-7
Verlag: https://doi.org/10.1186/s13075-015-0851-7
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Author Notes:Wolfgang Merkt, Prisca Sturm, Felix Lasitschka, Theresa Tretter, Carsten Watzl, Daniel Saure, Michael Hundemer, Vedat Schwenger, Norbert Blank, Hanns-Martin Lorenz and Adelheid Cerwenka
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Summary:The role of CD3−CD56+ natural killer (NK) cells in granulomatosis with polyangiitis (GPA) is poorly understood. Recently, it has been shown that peripheral blood NK cells can kill renal microvascular endothelial cells, suggesting a pathogenic role of NK cells in this disease. So far, subset distribution, phenotype, and function of peripheral blood NK cells in relation to GPA disease activity have not been elucidated. Moreover, it is not known whether NK cells infiltrate GPA tissue lesions.
Item Description:Gesehen am 29.05.2020
Physical Description:Online Resource
ISSN:1465-9913
DOI:10.1186/s13075-015-0851-7

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