Spinal excitatory mechanisms of pathological pain
An important property of the nociceptive system is its plasticity, ie, the ability to change in an experience-dependent manner, which is implicated in the transition from acute pain to chronic pathological pain. Disease-induced plasticity can occur at both structural and functional levels and manife...
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| Main Author: | |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
April 2015
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| In: |
Pain
Year: 2015, Volume: 156, Issue: 4, Pages: S11-S17 |
| ISSN: | 1872-6623 |
| DOI: | 10.1097/j.pain.0000000000000118 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1097/j.pain.0000000000000118 Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/pain/fulltext/2015/04001/Spinal_excitatory_mechanisms_of_pathological_pain.3.aspx 
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| Author Notes: | Rohini Kuner |
| Summary: | An important property of the nociceptive system is its plasticity, ie, the ability to change in an experience-dependent manner, which is implicated in the transition from acute pain to chronic pathological pain. Disease-induced plasticity can occur at both structural and functional levels and manifests as changes in individual molecules, synapses, cellular function, and network activity. In this short review, the author discusses how synaptic plasticity may mediate pathophysiological alterations linked to chronic pain by virtue of shifting the balance between excitation and inhibition, with a particular emphasis on the spinal dorsal horn. |
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| Item Description: | Gesehen am 03.06.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1872-6623 |
| DOI: | 10.1097/j.pain.0000000000000118 |