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A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses

Synaptic plasticity is the cornerstone of processes underlying persistent nociceptive activity-induced changes in normal nociceptive sensitivity. Kalirin-7 is a multifunctional guanine-nucleotide-exchange factor (GEF) for Rho GTPases that is characterized by its localization at excitatory synapses,...

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Bibliographic Details
Main Authors: Lu, Jianning (Author) , Luo, Ceng (Author) , Bali, Kiran Kumar (Author) , Xie, Rou-Gang (Author) , Mains, Richard E. (Author) , Eipper, Betty A. (Author) , Kuner, Rohini (Author)
Format: Article (Journal)
Language:English
Published: 13 April 2015
In: Nature Communications
Year: 2015, Volume: 6, Issue: 1
ISSN:2041-1723
DOI:10.1038/ncomms7820
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/ncomms7820
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/ncomms7820
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Author Notes:Jianning Lu, Ceng Luo, Kiran Kumar Bali, Rou-Gang Xie, Richard E. Mains, Betty A. Eipper & Rohini Kuner
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Summary:Synaptic plasticity is the cornerstone of processes underlying persistent nociceptive activity-induced changes in normal nociceptive sensitivity. Kalirin-7 is a multifunctional guanine-nucleotide-exchange factor (GEF) for Rho GTPases that is characterized by its localization at excitatory synapses, interactions with glutamate receptors and its ability to dynamically modulate the neuronal cytoskeleton. Here we show that spinally expressed Kalirin-7 is required for persistent nociceptive activity-dependent synaptic long-term potentiation as well as activity-dependent remodelling of synaptic spines in the spinal dorsal horn, thereby orchestrating functional and structural plasticity during the course of inflammatory pain.
Item Description:Gesehen am 03.06.2020
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/ncomms7820

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