Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease
Key Points. Heme and iron induce macrophage phenotypic switching toward an M1 proinflammatory phenotype.By scavenging free heme, hemopexin reverts heme-induced
Guardado en:
| Autores principales: | , , , , , , , , |
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| Formato: | Article (Journal) |
| Lenguaje: | inglés |
| Publicado: |
[28 January 2016]
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| In: |
Blood
Year: 2016, Volumen: 127, Número: 4, Pages: 473-486 |
| ISSN: | 1528-0020 |
| DOI: | 10.1182/blood-2015-08-663245 |
| Acceso en línea: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1182/blood-2015-08-663245 Verlag, lizenzpflichtig, Volltext: https://ashpublications.org/blood/article/127/4/473/35037/Hemopexin-therapy-reverts-heme-induced |
| Notas de Autor: | Francesca Vinchi, Milene Costa da Silva, Giada Ingoglia, Sara Petrillo, Nathan Brinkman, Adrian Zuercher, Adelheid Cerwenka, Emanuela Tolosano, Martina U. Muckenthaler |
| Sumario: | Key Points. Heme and iron induce macrophage phenotypic switching toward an M1 proinflammatory phenotype.By scavenging free heme, hemopexin reverts heme-induced |
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| Notas: | Gesehen am 04.06.2020 |
| Descripción Física: | Online Resource |
| ISSN: | 1528-0020 |
| DOI: | 10.1182/blood-2015-08-663245 |