Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease

Key Points. Heme and iron induce macrophage phenotypic switching toward an M1 proinflammatory phenotype.By scavenging free heme, hemopexin reverts heme-induced

Saved in:

Bibliographic Details
Main Authors:	Vinchi, Francesca (Author) , Costa da Silva, Milene (Author) , Ingoglia, Giada (Author) , Petrillo, Sara (Author) , Brinkman, Nathan (Author) , Zuercher, Adrian (Author) , Cerwenka, Adelheid (Author) , Tolosano, Emanuela (Author) , Muckenthaler, Martina (Author)
Format:	Article (Journal)
Language:	English
Published:	[28 January 2016]
In:	Blood Year: 2016, Volume: 127, Issue: 4, Pages: 473-486
ISSN:	1528-0020
DOI:	10.1182/blood-2015-08-663245
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1182/blood-2015-08-663245 Verlag, lizenzpflichtig, Volltext: https://ashpublications.org/blood/article/127/4/473/35037/Hemopexin-therapy-reverts-heme-induced
Author Notes:	Francesca Vinchi, Milene Costa da Silva, Giada Ingoglia, Sara Petrillo, Nathan Brinkman, Adrian Zuercher, Adelheid Cerwenka, Emanuela Tolosano, Martina U. Muckenthaler

Description
Summary:	Key Points. Heme and iron induce macrophage phenotypic switching toward an M1 proinflammatory phenotype.By scavenging free heme, hemopexin reverts heme-induced
Item Description:	Gesehen am 04.06.2020
Physical Description:	Online Resource
ISSN:	1528-0020
DOI:	10.1182/blood-2015-08-663245