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The Sur1-Trpm4 channel regulates NOS2 transcription in TLR4-activated microglia

Harmful effects of activated microglia are due, in part, to the formation of peroxynitrite radicals, which is attributable to the upregulation of inducible nitric oxide (NO) synthase (NOS2). Because NOS2 expression is determined by Ca2+-sensitive calcineurin (CN) dephosphorylating nuclear factor of...

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Main Authors: Kurland, David B. (Author) , Gerzanich, Volodymyr (Author) , Karimy, Jason K. (Author) , Woo, Seung Kyoon (Author) , Vennekens, Rudi (Author) , Freichel, Marc (Author) , Nilius, Bernd (Author) , Bryan, Joseph (Author) , Simard, J. Marc (Author)
Format: Article (Journal)
Language:English
Published: 01 June 2016
In: Journal of neuroinflammation
Year: 2016, Volume: 13, Pages: 1-23
ISSN:1742-2094
DOI:10.1186/s12974-016-0599-2
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12974-016-0599-2
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Author Notes:David B. Kurland, Volodymyr Gerzanich, Jason K. Karimy, Seung Kyoon Woo, Rudi Vennekens, Marc Freichel, Bernd Nilius, Joseph Bryan and J. Marc Simard
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Summary:Harmful effects of activated microglia are due, in part, to the formation of peroxynitrite radicals, which is attributable to the upregulation of inducible nitric oxide (NO) synthase (NOS2). Because NOS2 expression is determined by Ca2+-sensitive calcineurin (CN) dephosphorylating nuclear factor of activated T cells (NFAT), and because Sur1-Trpm4 channels are crucial for regulating Ca2+ influx, we hypothesized that, in activated microglia, Sur1-Trpm4 channels play a central role in regulating CN/NFAT and downstream target genes such as Nos2.
Item Description:Gesehen am 04.06.2020
Physical Description:Online Resource
ISSN:1742-2094
DOI:10.1186/s12974-016-0599-2

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