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Targeted deep sequencing of mucinous ovarian tumors reveals multiple overlapping RAS-pathway activating mutations in borderline and cancerous neoplasms

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Mucinous ovarian tumors represent a distinct histotype of epithelial ovarian cancer. The rarest (2-4 % of ovarian carcinomas) of the five major histotypes, their genomic landscape remains poorly described. We undertook hotspot sequencing of 50 genes commonly mutated in human cancer across 69 mucinou...

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Main Authors: Mackenzie, Robertson (Author) , Kommoss, Stefan (Author) , Winterhoff, Boris Jan Nils (Author) , Kipp, Benjamin R. (Author) , Garcia, Joaquin J. (Author) , Voss, Jesse (Author) , Halling, Kevin (Author) , Karnezis, Anthony (Author) , Senz, Janine (Author) , Yang, Winnie (Author) , Prigge, Elena-Sophie (Author) , Reuschenbach, Miriam (Author) , Knebel Doeberitz, Magnus von (Author) , Gilks, Blake C. (Author) , Huntsman, David G. (Author) , Bakkum-Gamez, Jamie (Author) , McAlpine, Jessica N. (Author) , Anglesio, Michael S. (Author)
Format: Article (Journal)
Language:English
Published: 19 May 2015
In: BMC cancer
Year: 2015, Volume: 15
ISSN:1471-2407
DOI:10.1186/s12885-015-1421-8
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12885-015-1421-8
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Author Notes:Robertson Mackenzie, Stefan Kommoss, Boris J. Winterhoff, Benjamin R. Kipp, Joaquin J. Garcia, Jesse Voss, Kevin Halling, Anthony Karnezis, Janine Senz, Winnie Yang, Elena-Sophie Prigge, Miriam Reuschenbach, Magnus Von Knebel Doeberitz, Blake C. Gilks, David G. Huntsman, Jamie Bakkum-Gamez, Jessica N. McAlpine and Michael S. Anglesio
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Summary:Mucinous ovarian tumors represent a distinct histotype of epithelial ovarian cancer. The rarest (2-4 % of ovarian carcinomas) of the five major histotypes, their genomic landscape remains poorly described. We undertook hotspot sequencing of 50 genes commonly mutated in human cancer across 69 mucinous ovarian tumors. Our goals were to establish the overall frequency of cancer-hotspot mutations across a large cohort, especially those tumors previously thought to be “RAS-pathway alteration negative”, using highly-sensitive next-generation sequencing as well as further explore a small number of cases with apparent heterogeneity in RAS-pathway activating alterations.
Item Description:Gesehen am 04.06.2020
Physical Description:Online Resource
ISSN:1471-2407
DOI:10.1186/s12885-015-1421-8

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