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Exploiting noncovalent interactions in an imine-based covalent organic framework for Quercetin delivery

Covalent organic frameworks (COFs) are a new class of nanoporous polymeric vector showing promise as drug-delivery vehicles with high loading capacity and biocompatibility. The interaction between the carrier and the cargo is specifically tailored on a molecular level by H-bonding. Cell-proliferatio...

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Main Authors: Vyas, Vijay S. (Author) , Vishwakarma, Medhavi (Author) , Moudrakovski, Igor (Author) , Haase, Frederik (Author) , Savasci, Gökcen (Author) , Ochsenfeld, Christian (Author) , Spatz, Joachim P. (Author) , Lotsch, Bettina V. (Author)
Format: Article (Journal)
Language:English
Published: [2016]
In: Advanced materials
Year: 2016, Volume: 28, Issue: 39, Pages: 8749-8754
ISSN:1521-4095
DOI:10.1002/adma.201603006
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/adma.201603006
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.201603006
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Author Notes:Vijay S. Vyas, Medhavi Vishwakarma, Igor Moudrakovski, Frederik Haase, Gökcen Savasci, Christian Ochsenfeld, Joachim P. Spatz, and Bettina V. Lotsch
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Summary:Covalent organic frameworks (COFs) are a new class of nanoporous polymeric vector showing promise as drug-delivery vehicles with high loading capacity and biocompatibility. The interaction between the carrier and the cargo is specifically tailored on a molecular level by H-bonding. Cell-proliferation studies indicate higher efficacy of the drug in cancer cells by nanocarrier delivery mediated by the COF.
Item Description:Gesehen am 04.06.2020
Physical Description:Online Resource
ISSN:1521-4095
DOI:10.1002/adma.201603006

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