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Ebola virus dynamics in mice treated with favipiravir

The polymerase inhibitor favipiravir is a candidate for the treatment of Ebola virus disease. Here, we designed a mathematical model to characterize the viral dynamics in 20 mice experimentally infected with Ebola virus, which were either left untreated or treated with favipiravir at 6 or 8days post...

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Main Authors: Madelain, Vincent (Author) , Oestereich, Lisa (Author) , Graw, Frederik (Author) , Nguyen, Thi Huyen Tram (Author) , de Lamballerie, Xavier (Author) , Mentré, France (Author) , Günther, Stephan (Author) , Guedj, Jeremie (Author)
Format: Article (Journal)
Language:English
Published: 2 September 2015
In: Antiviral research
Year: 2015, Volume: 123, Pages: 70-77
ISSN:1872-9096
DOI:10.1016/j.antiviral.2015.08.015
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.antiviral.2015.08.015
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0166354215002107
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Author Notes:Vincent Madelain, Lisa Oestereich, Frederik Graw, Thi Huyen Tram Nguyen, Xavier de Lamballerie, France Mentré, Stephan Günther, Jeremie Guedj
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Summary:The polymerase inhibitor favipiravir is a candidate for the treatment of Ebola virus disease. Here, we designed a mathematical model to characterize the viral dynamics in 20 mice experimentally infected with Ebola virus, which were either left untreated or treated with favipiravir at 6 or 8days post infection. This approach provided estimates of kinetic parameters of Ebola virus reproduction, such as the half-life of productively infected cells, of about 6h, and the basic reproductive number which indicates that virus produced by a single infected cell productively infects about 9 new cells. Furthermore, the model predicted that favipiravir efficiently blocks viral production, reaching an antiviral effectiveness of 95% and 99.6% at 2 and 6days after initiation of treatment, respectively. The model could be particularly helpful to guide future studies evaluating favipiravir in larger animals.
Item Description:Gesehen am 04.06.2020
Physical Description:Online Resource
ISSN:1872-9096
DOI:10.1016/j.antiviral.2015.08.015

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