Patch testing to a textile dye mix by the International Contact Dermatitis Research Group

Disperse dyes are well-known contact sensitizers not included in the majority of commercially available baseline series. - Objective - To investigate the outcome of patch testing to a textile dye mix (TDM) consisting of 8 disperse dyes. - Methods - Two thousand four hundred ninety-th...

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Hauptverfasser: Isaksson, Marléne (VerfasserIn) , Diepgen, Thomas L. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: Jul 1, 2015
In: Dermatitis
Year: 2015, Jahrgang: 26, Heft: 4, Pages: 170-176
ISSN:2162-5220
DOI:10.1097/DER.0000000000000125
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/DER.0000000000000125
Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/dermatitis/Abstract/2015/07000/Patch_Testing_To_a_Textile_Dye_Mix_by_the.5.aspx
Volltext
Verfasserangaben:Isaksson, Marléne MD, PhD; Ale, Iris MD; Andersen, Klaus E. MD, DMSc; Diepgen, Thomas MD, PhD; Goh, Chee-Leok MD, MRCP(UK), FRCPE, MMed; Goossens R, An Pharm, PhD; Jerajani, Hemangi MD, DV&D; Maibach, Howard I. MD; Sasseville, Denis MD, FRCPC; Bruze, Magnus MD, PhD

MARC

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520 |a Disperse dyes are well-known contact sensitizers not included in the majority of commercially available baseline series. - Objective - To investigate the outcome of patch testing to a textile dye mix (TDM) consisting of 8 disperse dyes. - Methods - Two thousand four hundred ninety-three consecutive dermatitis patients in 9 dermatology clinics were patch tested with a TDM 6.6%, consisting of Disperse (D) Blue 35, D Yellow 3, D Orange 1 and 3, D Red 1 and 17, all 1.0% each, and D Blue 106 and D Blue 124, each 0.3%. 90 reacted positively to the TDM. About 92.2% of the patients allergic to the TDM were also tested with the 8 separate dyes. - Results - Contact allergy to TDM was found in 3.6% (1.3-18.2) Simultaneous reactivity to p-phenylenediamine was found in 61.1% of the TDM-positive patients. Contact allergy to TDM and not to other p-amino-substituted sensitizers was diagnosed in 1.2%. The most frequent dye allergen in the TDM-positive patients was D Orange 3. - Conclusions - Over 30% of the TDM allergic patients had been missed if only the international baseline series was tested. Contact allergy to TDM could explain or contribute to dermatitis in over 20% of the patients. Textile dye mix should be considered for inclusion into the international baseline series. 
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