Regulation of distinct branches of the non-canonical Wnt-signaling network in Xenopus dorsal marginal zone explants
A tight regulation of the Wnt-signaling network, activated by 19 Wnt molecules and numerous receptors and co-receptors, is required for the establishment of a complex organism. Different branches of this Wnt-signaling network, including the canonical Wnt/β-catenin and the non-canonical Wnt/PCP, Wnt/...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
05 July 2016
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| In: |
BMC biology
Year: 2016, Volume: 14 |
| ISSN: | 1741-7007 |
| DOI: | 10.1186/s12915-016-0278-x |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12915-016-0278-x
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| Author Notes: | Veronika Wallkamm, Karolin Rahm, Jana Schmoll, Lilian T. Kaufmann, Eva Brinkmann, Jessica Schunk, Bianca Kraft, Doris Wedlich and Dietmar Gradl |
| Summary: | A tight regulation of the Wnt-signaling network, activated by 19 Wnt molecules and numerous receptors and co-receptors, is required for the establishment of a complex organism. Different branches of this Wnt-signaling network, including the canonical Wnt/β-catenin and the non-canonical Wnt/PCP, Wnt/Ror2 and Wnt/Ca2+ pathways, are assigned to distinct developmental processes and are triggered by certain ligand/receptor complexes. The Wnt-signaling molecules are closely related and it is still on debate whether the information for activating a specific branch is encoded by specific sequence motifs within a particular Wnt protein. The model organism Xenopus offers tools to distinguish between Wnt-signaling molecules activating distinct branches of the network. |
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| Item Description: | Gesehen am 05.06.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1741-7007 |
| DOI: | 10.1186/s12915-016-0278-x |