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Heterochromatin protein 1β (HP1β) has distinct functions and distinct nuclear distribution in pluripotent versus differentiated cells

Pluripotent embryonic stem cells (ESCs) have the unique ability to differentiate into every cell type and to self-renew. These characteristics correlate with a distinct nuclear architecture, epigenetic signatures enriched for active chromatin marks and hyperdynamic binding of structural chromatin pr...

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Main Authors: Mattout, Anna (Author) , Aaronson, Yair (Author) , Sailaja, Badi Sri (Author) , Raghu Ram, Edupuganti V. (Author) , Harikumar, Arigela (Author) , Mallm, Jan-Philipp (Author) , Sim, Kae Hwan (Author) , Nissim-Rafinia, Malka (Author) , Supper, Emmanuelle (Author) , Singh, Prim B. (Author) , Sze, Siu Kwan (Author) , Gasser, Susan M. (Author) , Rippe, Karsten (Author) , Meshorer, Eran (Author)
Format: Article (Journal)
Language:English
Published: 28 September 2015
In: Genome biology
Year: 2015, Volume: 16
ISSN:1474-760X
DOI:10.1186/s13059-015-0760-8
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13059-015-0760-8
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Author Notes:Anna Mattout, Yair Aaronson, Badi Sri Sailaja, Edupuganti V. Raghu Ram, Arigela Harikumar, Jan-Philipp Mallm, Kae Hwan Sim, Malka Nissim-Rafinia, Emmanuelle Supper, Prim B. Singh, Siu Kwan Sze, Susan M. Gasser, Karsten Rippe and Eran Meshorer
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Summary:Pluripotent embryonic stem cells (ESCs) have the unique ability to differentiate into every cell type and to self-renew. These characteristics correlate with a distinct nuclear architecture, epigenetic signatures enriched for active chromatin marks and hyperdynamic binding of structural chromatin proteins. Recently, several chromatin-related proteins have been shown to regulate ESC pluripotency and/or differentiation, yet the role of the major heterochromatin proteins in pluripotency is unknown.
Item Description:Gesehen am 09.06.2020
Physical Description:Online Resource
ISSN:1474-760X
DOI:10.1186/s13059-015-0760-8

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