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Heterochromatin protein 1β (HP1β) has distinct functions and distinct nuclear distribution in pluripotent versus differentiated cells

Pluripotent embryonic stem cells (ESCs) have the unique ability to differentiate into every cell type and to self-renew. These characteristics correlate with a distinct nuclear architecture, epigenetic signatures enriched for active chromatin marks and hyperdynamic binding of structural chromatin pr...

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Hauptverfasser: Mattout, Anna (VerfasserIn) , Aaronson, Yair (VerfasserIn) , Sailaja, Badi Sri (VerfasserIn) , Raghu Ram, Edupuganti V. (VerfasserIn) , Harikumar, Arigela (VerfasserIn) , Mallm, Jan-Philipp (VerfasserIn) , Sim, Kae Hwan (VerfasserIn) , Nissim-Rafinia, Malka (VerfasserIn) , Supper, Emmanuelle (VerfasserIn) , Singh, Prim B. (VerfasserIn) , Sze, Siu Kwan (VerfasserIn) , Gasser, Susan M. (VerfasserIn) , Rippe, Karsten (VerfasserIn) , Meshorer, Eran (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 28 September 2015
In: Genome biology
Year: 2015, Jahrgang: 16
ISSN:1474-760X
DOI:10.1186/s13059-015-0760-8
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13059-015-0760-8
Volltext
Verfasserangaben:Anna Mattout, Yair Aaronson, Badi Sri Sailaja, Edupuganti V. Raghu Ram, Arigela Harikumar, Jan-Philipp Mallm, Kae Hwan Sim, Malka Nissim-Rafinia, Emmanuelle Supper, Prim B. Singh, Siu Kwan Sze, Susan M. Gasser, Karsten Rippe and Eran Meshorer
Beschreibung
Zusammenfassung:Pluripotent embryonic stem cells (ESCs) have the unique ability to differentiate into every cell type and to self-renew. These characteristics correlate with a distinct nuclear architecture, epigenetic signatures enriched for active chromatin marks and hyperdynamic binding of structural chromatin proteins. Recently, several chromatin-related proteins have been shown to regulate ESC pluripotency and/or differentiation, yet the role of the major heterochromatin proteins in pluripotency is unknown.
Beschreibung:Gesehen am 09.06.2020
Beschreibung:Online Resource
ISSN:1474-760X
DOI:10.1186/s13059-015-0760-8

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