Cover Image

FASN is a biomarker enriched in malignant glioma-derived extracellular vesicles

Extracellular vesicles (EVs) are known for their important role in cancer progression and hold considerable potential as a source for tumor biomarkers. However, purification of tumor-specific EVs from patient plasma is still an urgent unmet need due to contamination by normal host cell-derived EVs,...

Full description

Saved in:
Bibliographic Details
Main Authors: Ricklefs, Franz Lennard (Author) , Maire, Cecile L. (Author) , Matschke, Jakob (Author) , Dührsen, Lasse (Author) , Sauvigny, Thomas (Author) , Holz, Mareike (Author) , Kolbe, Katharina (Author) , Peine, Sven (Author) , Herold-Mende, Christel (Author) , Carter, Bob (Author) , Chiocca, E. Antonio (Author) , Lawler, Sean E. (Author) , Westphal, Manfred (Author) , Lamszus, Katrin (Author)
Format: Article (Journal)
Language:English
Published: 12 March 2020
In: International journal of molecular sciences
Year: 2020, Volume: 21, Issue: 6
ISSN:1422-0067
DOI:10.3390/ijms21061931
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/ijms21061931
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1422-0067/21/6/1931
Get full text
Author Notes:Franz L. Ricklefs, Cecile L. Maire, Jakob Matschke, Lasse Dührsen, Thomas Sauvigny, Mareike Holz, Katharina Kolbe, Sven Peine, Christel Herold-Mende, Bob Carter, E. Antonio Chiocca, Sean E. Lawler, Manfred Westphal, Katrin Lamszus
Description
Summary:Extracellular vesicles (EVs) are known for their important role in cancer progression and hold considerable potential as a source for tumor biomarkers. However, purification of tumor-specific EVs from patient plasma is still an urgent unmet need due to contamination by normal host cell-derived EVs, that results in compromised analytical sensitivity. Here we identified fatty acid synthase (FASN), a key lipogenic enzyme which is highly expressed in malignant glioma cells, to be elevated in CD63- and CD81-positive EVs in glioma patient plasma samples, opening vital opportunities to sort brain tumor-specific EVs.
Item Description:Gesehen am 10.06.2020
Physical Description:Online Resource
ISSN:1422-0067
DOI:10.3390/ijms21061931

Similar Items