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Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma

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An inverse correlation between expression of the aldehyde dehydrogenase 1 subfamily A2 (ALDH1A2) and gene promoter methylation has been identified as a common feature of oropharyngeal squamous cell carcinoma (OPSCC). Moreover, low ALDH1A2 expression was associated with an unfavorable prognosis of OP...

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Main Authors: Seidensaal, Katharina (Author) , Nollert, André (Author) , Feige, Agnes Hiou (Author) , Muller, Marie France (Author) , Fleming, Thomas (Author) , Gunkel, Nikolas (Author) , Plath, Karim (Author) , Grabe, Niels (Author) , Weichert, Wilko (Author) , Weber, Klaus-Josef (Author) , Plinkert, Peter K. (Author) , Simon, Christian (Author) , Heß, Jochen (Author)
Format: Article (Journal)
Language:English
Published: 3 December 2015
In: Molecular cancer
Year: 2015, Volume: 14, Pages: 1-13
ISSN:1476-4598
DOI:10.1186/s12943-015-0476-0
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12943-015-0476-0
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Author Notes:Katharina Seidensaal, Andre Nollert, Agnes Hiou Feige, Marie Muller, Thomas Fleming, Nikolas Gunkel, Karim Zaoui, Niels Grabe, Wilko Weichert, Klaus-Josef Weber, Peter Plinkert, Christian Simon, Jochen Hess
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Summary:An inverse correlation between expression of the aldehyde dehydrogenase 1 subfamily A2 (ALDH1A2) and gene promoter methylation has been identified as a common feature of oropharyngeal squamous cell carcinoma (OPSCC). Moreover, low ALDH1A2 expression was associated with an unfavorable prognosis of OPSCC patients, however the causal link between reduced ALDH1A2 function and treatment failure has not been addressed so far.
Item Description:Gesehen am 15.06.020
Physical Description:Online Resource
ISSN:1476-4598
DOI:10.1186/s12943-015-0476-0

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