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Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma

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An inverse correlation between expression of the aldehyde dehydrogenase 1 subfamily A2 (ALDH1A2) and gene promoter methylation has been identified as a common feature of oropharyngeal squamous cell carcinoma (OPSCC). Moreover, low ALDH1A2 expression was associated with an unfavorable prognosis of OP...

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Main Authors: Seidensaal, Katharina (Author) , Nollert, André (Author) , Feige, Agnes Hiou (Author) , Muller, Marie France (Author) , Fleming, Thomas (Author) , Gunkel, Nikolas (Author) , Plath, Karim (Author) , Grabe, Niels (Author) , Weichert, Wilko (Author) , Weber, Klaus-Josef (Author) , Plinkert, Peter K. (Author) , Simon, Christian (Author) , Heß, Jochen (Author)
Format: Article (Journal)
Language:English
Published: 3 December 2015
In: Molecular cancer
Year: 2015, Volume: 14, Pages: 1-13
ISSN:1476-4598
DOI:10.1186/s12943-015-0476-0
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12943-015-0476-0
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Author Notes:Katharina Seidensaal, Andre Nollert, Agnes Hiou Feige, Marie Muller, Thomas Fleming, Nikolas Gunkel, Karim Zaoui, Niels Grabe, Wilko Weichert, Klaus-Josef Weber, Peter Plinkert, Christian Simon, Jochen Hess
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Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck s... by Seidensaal, Katharina (Author) , Nollert, André (Author) , Fleming, Thomas (Author) , Plath, Karim (Author) , Grabe, Niels (Author) , Weichert, Wilko (Author) , Weber, Klaus-Josef (Author) , Plinkert, Peter K. (Author) , Heß, Jochen (Author) ,

BioMed Central 2015

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