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The CatSper channel controls chemosensation in sea urchin sperm

Sperm guidance is controlled by chemical and physical cues. In many species, Ca2+ bursts in the flagellum govern navigation to the egg. In Arbacia punctulata, a model system of sperm chemotaxis, a cGMP signaling pathway controls these Ca2+ bursts. The underlying Ca2+ channel and its mechanisms of ac...

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Main Authors: Seifert, Reinhard (Author) , Flick, Melanie (Author) , Bönigk, Wolfgang (Author) , Alvarez, Luis (Author) , Trötschel, Christian (Author) , Poetsch, Ansgar (Author) , Müller, Astrid (Author) , Goodwin, Normann (Author) , Pelzer, Patric (Author) , Kashikar, Nachiket D (Author) , Kremmer, Elisabeth (Author) , Jikeli, Jan (Author) , Timmermann, Bernd (Author) , Kuhl, Heiner (Author) , Fridman, Dmitry (Author) , Windler, Florian (Author) , Kaupp, U Benjamin (Author) , Strünker, Timo (Author)
Format: Article (Journal)
Language:English
Published: 2015
In: The EMBO journal
Year: 2014, Volume: 34, Issue: 3, Pages: 379-392
ISSN:1460-2075
DOI:10.15252/embj.201489376
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.15252/embj.201489376
Verlag, lizenzpflichtig, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339123/
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Author Notes:Reinhard Seifert, Melanie Flick, Wolfgang Bönigk, Luis Alvarez, Christian Trötschel, Ansgar Poetsch, Astrid Müller, Normann Goodwin, Patric Pelzer, Nachiket D Kashikar, Elisabeth Kremmer, Jan Jikeli, Bernd Timmermann, Heiner Kuhl, Dmitry Fridman, Florian Windler, U Benjamin Kaup &, Timo Strünker
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Summary:Sperm guidance is controlled by chemical and physical cues. In many species, Ca2+ bursts in the flagellum govern navigation to the egg. In Arbacia punctulata, a model system of sperm chemotaxis, a cGMP signaling pathway controls these Ca2+ bursts. The underlying Ca2+ channel and its mechanisms of activation are unknown. Here, we identify CatSper Ca2+ channels in the flagellum of A. punctulata sperm. We show that CatSper mediates the chemoattractant-evoked Ca2+ influx and controls chemotactic steering; a concomitant alkalization serves as a highly cooperative mechanism that enables CatSper to transduce periodic voltage changes into Ca2+ bursts. Our results reveal intriguing phylogenetic commonalities but also variations between marine invertebrates and mammals regarding the function and control of CatSper. The variations probably reflect functional and mechanistic adaptations that evolved during the transition from external to internal fertilization.
Item Description:Published online 22 December 2014
Gesehen am 16.06.2020
Physical Description:Online Resource
ISSN:1460-2075
DOI:10.15252/embj.201489376

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