The CatSper channel controls chemosensation in sea urchin sperm
Sperm guidance is controlled by chemical and physical cues. In many species, Ca2+ bursts in the flagellum govern navigation to the egg. In Arbacia punctulata, a model system of sperm chemotaxis, a cGMP signaling pathway controls these Ca2+ bursts. The underlying Ca2+ channel and its mechanisms of ac...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2015
|
| In: |
The EMBO journal
Year: 2014, Jahrgang: 34, Heft: 3, Pages: 379-392 |
| ISSN: | 1460-2075 |
| DOI: | 10.15252/embj.201489376 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.15252/embj.201489376 Verlag, lizenzpflichtig, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339123/ 
|
| Verfasserangaben: | Reinhard Seifert, Melanie Flick, Wolfgang Bönigk, Luis Alvarez, Christian Trötschel, Ansgar Poetsch, Astrid Müller, Normann Goodwin, Patric Pelzer, Nachiket D Kashikar, Elisabeth Kremmer, Jan Jikeli, Bernd Timmermann, Heiner Kuhl, Dmitry Fridman, Florian Windler, U Benjamin Kaup &, Timo Strünker |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1700630075 | ||
| 003 | DE-627 | ||
| 005 | 20240406193212.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200616r20152014xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.15252/embj.201489376 |2 doi | |
| 035 | |a (DE-627)1700630075 | ||
| 035 | |a (DE-599)KXP1700630075 | ||
| 035 | |a (OCoLC)1341339623 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Seifert, Reinhard |e VerfasserIn |0 (DE-588)1212044452 |0 (DE-627)1700632876 |4 aut | |
| 245 | 1 | 4 | |a The CatSper channel controls chemosensation in sea urchin sperm |c Reinhard Seifert, Melanie Flick, Wolfgang Bönigk, Luis Alvarez, Christian Trötschel, Ansgar Poetsch, Astrid Müller, Normann Goodwin, Patric Pelzer, Nachiket D Kashikar, Elisabeth Kremmer, Jan Jikeli, Bernd Timmermann, Heiner Kuhl, Dmitry Fridman, Florian Windler, U Benjamin Kaup &, Timo Strünker |
| 264 | 1 | |c 2015 | |
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Published online 22 December 2014 | ||
| 500 | |a Gesehen am 16.06.2020 | ||
| 520 | |a Sperm guidance is controlled by chemical and physical cues. In many species, Ca2+ bursts in the flagellum govern navigation to the egg. In Arbacia punctulata, a model system of sperm chemotaxis, a cGMP signaling pathway controls these Ca2+ bursts. The underlying Ca2+ channel and its mechanisms of activation are unknown. Here, we identify CatSper Ca2+ channels in the flagellum of A. punctulata sperm. We show that CatSper mediates the chemoattractant-evoked Ca2+ influx and controls chemotactic steering; a concomitant alkalization serves as a highly cooperative mechanism that enables CatSper to transduce periodic voltage changes into Ca2+ bursts. Our results reveal intriguing phylogenetic commonalities but also variations between marine invertebrates and mammals regarding the function and control of CatSper. The variations probably reflect functional and mechanistic adaptations that evolved during the transition from external to internal fertilization. | ||
| 534 | |c 2014 | ||
| 700 | 1 | |a Flick, Melanie |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bönigk, Wolfgang |e VerfasserIn |4 aut | |
| 700 | 1 | |a Alvarez, Luis |e VerfasserIn |4 aut | |
| 700 | 1 | |a Trötschel, Christian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Poetsch, Ansgar |e VerfasserIn |4 aut | |
| 700 | 1 | |a Müller, Astrid |e VerfasserIn |4 aut | |
| 700 | 1 | |a Goodwin, Normann |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pelzer, Patric |e VerfasserIn |0 (DE-588)1099733375 |0 (DE-627)858752980 |0 (DE-576)469354208 |4 aut | |
| 700 | 1 | |a Kashikar, Nachiket D |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kremmer, Elisabeth |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jikeli, Jan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Timmermann, Bernd |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kuhl, Heiner |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fridman, Dmitry |e VerfasserIn |4 aut | |
| 700 | 1 | |a Windler, Florian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kaupp, U Benjamin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Strünker, Timo |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |a European Molecular Biology Organization |t The EMBO journal |d [London] : Nature Publishing Group UK, 1982 |g 34(2015), 3, Seite 379-392 |h Online-Ressource |w (DE-627)266022529 |w (DE-600)1467419-1 |w (DE-576)075961377 |x 1460-2075 |7 nnas |
| 773 | 1 | 8 | |g volume:34 |g year:2015 |g number:3 |g pages:379-392 |g extent:14 |a The CatSper channel controls chemosensation in sea urchin sperm |
| 856 | 4 | 0 | |u https://doi.org/10.15252/embj.201489376 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339123/ |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200616 | ||
| 993 | |a Article | ||
| 994 | |a 2015 | ||
| 998 | |g 1099733375 |a Pelzer, Patric |m 1099733375:Pelzer, Patric |p 9 | ||
| 999 | |a KXP-PPN1700630075 |e 3687411672 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedKey":"2015","dateIssuedDisp":"2015"}],"id":{"eki":["1700630075"],"doi":["10.15252/embj.201489376"]},"name":{"displayForm":["Reinhard Seifert, Melanie Flick, Wolfgang Bönigk, Luis Alvarez, Christian Trötschel, Ansgar Poetsch, Astrid Müller, Normann Goodwin, Patric Pelzer, Nachiket D Kashikar, Elisabeth Kremmer, Jan Jikeli, Bernd Timmermann, Heiner Kuhl, Dmitry Fridman, Florian Windler, U Benjamin Kaup &, Timo Strünker"]},"physDesc":[{"extent":"14 S."}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"name":{"displayForm":["publ. for the European Molecular Biology Organization"]},"origin":[{"publisherPlace":"[London] ; Heidelberg ; Oxford [u.a.] ; London [u.a.] ; Hoboken, NJ [u.a.]","dateIssuedDisp":"1982-","dateIssuedKey":"1982","publisher":"Nature Publishing Group UK ; EMBO Press ; Oxford Univ. Press ; Nature Publ. Group ; Wiley"}],"id":{"doi":["10.1002/(ISSN)1460-2075"],"eki":["266022529"],"zdb":["1467419-1"],"issn":["1460-2075"]},"note":["Gesehen am 18.02.2016","Fortsetzung der Druckausgabe"],"disp":"European Molecular Biology OrganizationThe EMBO journal","type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"266022529","corporate":[{"display":"European Molecular Biology Organization","roleDisplay":"VerfasserIn","role":"aut"}],"language":["eng"],"pubHistory":["1.1982 -"],"part":{"volume":"34","text":"34(2015), 3, Seite 379-392","extent":"14","year":"2015","issue":"3","pages":"379-392"},"titleAlt":[{"title":"The EMBO journal online"}],"title":[{"title":"The EMBO journal","title_sort":"EMBO journal"}]}],"title":[{"title":"The CatSper channel controls chemosensation in sea urchin sperm","title_sort":"CatSper channel controls chemosensation in sea urchin sperm"}],"person":[{"role":"aut","roleDisplay":"VerfasserIn","display":"Seifert, Reinhard","given":"Reinhard","family":"Seifert"},{"family":"Flick","given":"Melanie","roleDisplay":"VerfasserIn","display":"Flick, Melanie","role":"aut"},{"family":"Bönigk","given":"Wolfgang","display":"Bönigk, Wolfgang","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Luis","family":"Alvarez","role":"aut","roleDisplay":"VerfasserIn","display":"Alvarez, Luis"},{"role":"aut","display":"Trötschel, Christian","roleDisplay":"VerfasserIn","given":"Christian","family":"Trötschel"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Poetsch, Ansgar","given":"Ansgar","family":"Poetsch"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Müller, Astrid","given":"Astrid","family":"Müller"},{"given":"Normann","family":"Goodwin","role":"aut","display":"Goodwin, Normann","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","display":"Pelzer, Patric","role":"aut","family":"Pelzer","given":"Patric"},{"roleDisplay":"VerfasserIn","display":"Kashikar, Nachiket D","role":"aut","family":"Kashikar","given":"Nachiket D"},{"display":"Kremmer, Elisabeth","roleDisplay":"VerfasserIn","role":"aut","family":"Kremmer","given":"Elisabeth"},{"family":"Jikeli","given":"Jan","roleDisplay":"VerfasserIn","display":"Jikeli, Jan","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Timmermann, Bernd","role":"aut","family":"Timmermann","given":"Bernd"},{"family":"Kuhl","given":"Heiner","roleDisplay":"VerfasserIn","display":"Kuhl, Heiner","role":"aut"},{"given":"Dmitry","family":"Fridman","role":"aut","display":"Fridman, Dmitry","roleDisplay":"VerfasserIn"},{"given":"Florian","family":"Windler","role":"aut","display":"Windler, Florian","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","display":"Kaupp, U Benjamin","role":"aut","family":"Kaupp","given":"U Benjamin"},{"family":"Strünker","given":"Timo","display":"Strünker, Timo","roleDisplay":"VerfasserIn","role":"aut"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Published online 22 December 2014","Gesehen am 16.06.2020"],"recId":"1700630075","language":["eng"]} | ||
| SRT | |a SEIFERTREICATSPERCHA2015 | ||