IKZF1/3 and CRL4 (CRBN) E3 ubiquitin ligase mutations and resistance to immunomodulatory drugs in multiple myeloma

Cereblon (CRBN), a target of immunomodulatory drugs (IMiD), forms the CRL4CRBN E3 ubiquitin ligase (CRL4) complex with DDB1, CUL4B and ROC1.[1][1],[2][2] Under the influence of IMiD, CRL4 polyubiquitinates and thus depletes the transcription factors IKZF1 and IKZF3, resulting in cytotoxicity to

Bibliographic Details

Main Authors:	Barrio, Santiago (Author) , Munawar, Umair (Author) , Zhu, Yuan Xiao (Author) , Giesen, Nicola (Author) , Shi, Chang-Xin (Author) , Viá, Matteo Da (Author) , Sanchez, Ricardo (Author) , Bruins, Laura (Author) , Demler, Theresa (Author) , Müller, Nicole (Author) , Haertle, Larissa (Author) , Garitano, Andoni (Author) , Steinbrunn, Torsten (Author) , Danhof, Sophia (Author) , Cuenca, Isabel (Author) , Barrio García, Clara (Author) , Braggio, Esteban (Author) , Rosenwald, Andreas (Author) , Martinez-Lopez, Joaquin (Author) , Rasche, Leo (Author) , Raab, Marc-Steffen (Author) , Stewart, A. Keith (Author) , Einsele, Hermann (Author) , Stühmer, Thorsten (Author) , Kortüm, K. Martin (Author)
Format:	Article (Journal) Editorial
Language:	English
Published:	May 2020
In:	Haematologica Year: 2020, Volume: 105, Issue: 5, Pages: e237-e241
ISSN:	1592-8721
DOI:	10.3324/haematol.2019.217943
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3324/haematol.2019.217943 Verlag, lizenzpflichtig, Volltext: http://www.haematologica.org/content/105/5/e237
Author Notes:	Santiago Barrio, Umair Munawar, Yuan Xiao Zhu, Nicola Giesen, Chang-Xin Shi, Matteo Da Viá, Ricardo Sanchez, Laura Bruins, Theresa Demler, Nicole Müller, Larissa Haertle, Andoni Garitano, Torsten Steinbrunn, Sophia Danhof, Isabel Cuenca, Clara Barrio-Garcia, Esteban Braggio, Andreas Rosenwald, Joaquin Martinez-Lopez, Leo Rasche, Marc S. Raab, A. Keith Stewart, Hermann Einsele, Thorsten Stühmer, K. Martin Kortüm