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Impact of vesicular stomatitis virus M proteins on different cellular functions

Three different matrix (M) proteins termed M1, M2 and M3 have been described in cells infected with vesicular stomatitis virus (VSV). Individual expression of VSV M proteins induces an evident cytopathic effect including cell rounding and detachment, in addition to a partial inhibition of cellular p...

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Bibliographic Details
Main Authors: Redondo Rodríguez, Natalia (Author) , Madan Renes, Vanesa (Author) , Alvarez, Enrique (Author) , Carrasco, Luis (Author)
Format: Article (Journal)
Language:English
Published: June 19, 2015
In: PLOS ONE
Year: 2015, Volume: 10, Issue: 6
ISSN:1932-6203
DOI:10.1371/journal.pone.0131137
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1371/journal.pone.0131137
Verlag, lizenzpflichtig, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131137
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Author Notes:Natalia Redondo, Vanesa Madan, Enrique Alvarez, Luis Carrasco
Description
Summary:Three different matrix (M) proteins termed M1, M2 and M3 have been described in cells infected with vesicular stomatitis virus (VSV). Individual expression of VSV M proteins induces an evident cytopathic effect including cell rounding and detachment, in addition to a partial inhibition of cellular protein synthesis, likely mediated by an indirect mechanism. Analogous to viroporins, M1 promotes the budding of new virus particles; however, this process does not produce an increase in plasma membrane permeability. In contrast to M1, M2 and M3 neither interact with the cellular membrane nor promote the budding of double membrane vesicles at the cell surface. Nonetheless, all three species of M protein interfere with the transport of cellular mRNAs from the nucleus to the cytoplasm and also modulate the redistribution of the splicing factor. The present findings indicate that all three VSV M proteins share some activities that interfere with host cell functions.
Item Description:Gesehen am 17.06.2020
Physical Description:Online Resource
ISSN:1932-6203
DOI:10.1371/journal.pone.0131137

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