Implementation of Hadamard encoding for rapid multisample analysis in liquid chromatography
Multiplexing based on pseudo-binary modulation sequences is known to increase the signal-to-noise ratio. In this work, Hadamard transform multiplexing is used in high-performance liquid chromatography to increase the sample throughput. Using structured modulation sequences to encode and control samp...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
10 September 2015
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| In: |
Journal of separation science
Year: 2015, Volume: 38, Issue: 22, Pages: 3839-3844 |
| ISSN: | 1615-9314 |
| DOI: | 10.1002/jssc.201500849 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/jssc.201500849 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/jssc.201500849 
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| Author Notes: | Alexander F. Siegle, Oliver Trapp |
| Summary: | Multiplexing based on pseudo-binary modulation sequences is known to increase the signal-to-noise ratio. In this work, Hadamard transform multiplexing is used in high-performance liquid chromatography to increase the sample throughput. Using structured modulation sequences to encode and control sample injections in combination with a fitting algorithm to deconvolute the complex data allowed us to evaluate convoluted chromatograms of up to 128 samples containing three and five analytes, respectively, with good accuracy (<2% deviation). In comparison to conventional high-performance liquid chromatography the analysis time could be reduced by 30 and 55%, respectively. |
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| Item Description: | Gesehen am 17.06.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1615-9314 |
| DOI: | 10.1002/jssc.201500849 |