Cover Image

Structural analysis of a feline norovirus protruding domain

Norovirus infects different animals, including humans, mice, dogs, and cats. Here, we show an X-ray crystal structure of a feline GIV.2 norovirus capsid-protruding (P) domain to 2.35Å resolution. The feline GIV.2 P domain was reminiscent of human norovirus P domains, except for a novel P2 subdomain...

Full description

Saved in:
Bibliographic Details
Main Authors: Singh, Bishal (Author) , Glatt, Sebastian (Author) , Ferrer, Jean-Luc (Author) , Koromyslova, Anna D. (Author) , Leuthold, Mila (Author) , Dunder, Jessica (Author) , Hansman, Grant S. (Author)
Format: Article (Journal)
Language:English
Published: 2015
In: Virology
Year: 2014, Volume: 474, Pages: 181-185
ISSN:1096-0341
DOI:10.1016/j.virol.2014.10.028
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.virol.2014.10.028
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0042682214004851
Get full text
Author Notes:Bishal K. Singh, Sebastian Glatt, Jean-Luc Ferrer, Anna D. Koromyslova, Mila M. Leuthold, Jessica Dunder, Grant S. Hansman
Description
Summary:Norovirus infects different animals, including humans, mice, dogs, and cats. Here, we show an X-ray crystal structure of a feline GIV.2 norovirus capsid-protruding (P) domain to 2.35Å resolution. The feline GIV.2 P domain was reminiscent of human norovirus P domains, except for a novel P2 subdomain α-helix and an extended P1 subdomain interface loop. These new structural features likely obstructed histo-blood group antigens, which are attachment factors for human norovirus, from binding at the equivalent sites on the feline GIV.2 P domain. Additionally, an ELISA showed that the feline GIV.2 was antigenically distinct from a human GII.10 norovirus.
Item Description:Available online 19 November 2014
Gesehen am 17.06.2020
Physical Description:Online Resource
ISSN:1096-0341
DOI:10.1016/j.virol.2014.10.028

Similar Items