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Feasibility study on cardiac arrhythmia ablation using high-energy heavy ion beams

High-energy ion beams are successfully used in cancer therapy and precisely deliver high doses of ionizing radiation to small deep-seated target volumes. A similar noninvasive treatment modality for cardiac arrhythmias was tested here. This study used high-energy carbon ions for ablation of cardiac...

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Main Authors: Lehmann, Helge Immo (Author) , Graeff, Christian (Author) , Simoniello, Palma (Author) , Constantinescu, Anna (Author) , Takami, Mitsuru (Author) , Lugenbiel, Patrick (Author) , Richter, Daniel (Author) , Eichhorn, Anna (Author) , Prall, Matthias (Author) , Kaderka, Robert (Author) , Fiedler, Fine (Author) , Helmbrecht, Stephan (Author) , Fournier, Claudia (Author) , Erbeldinger, Nadine (Author) , Rahm, Ann-Kathrin (Author) , Rivinius, Rasmus (Author) , Thomas, Dierk (Author) , Katus, Hugo (Author) , Johnson, Susan B. (Author) , Parker, Kay D. (Author) , Debus, Jürgen (Author) , Asirvatham, Samuel J. (Author) , Bert, Christoph (Author) , Durante, Marco (Author) , Packer, Douglas L. (Author)
Format: Article (Journal)
Language:English
Published: 20 December 2016
In: Scientific reports
Year: 2016, Volume: 6
ISSN:2045-2322
DOI:10.1038/srep38895
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/srep38895
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/srep38895
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Author Notes:H. Immo Lehmann, Christian Graeff, Palma Simoniello, Anna Constantinescu, Mitsuru Takami, Patrick Lugenbiel, Daniel Richter, Anna Eichhorn, Matthias Prall, Robert Kaderka, Fine Fiedler, Stephan Helmbrecht, Claudia Fournier, Nadine Erbeldinger, Ann-Kathrin Rahm, Rasmus Rivinius, Dierk Thomas, Hugo A. Katus, Susan B. Johnson, Kay D. Parker, Jürgen Debus, Samuel J. Asirvatham, Christoph Bert, Marco Durante & Douglas L. Packer
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Summary:High-energy ion beams are successfully used in cancer therapy and precisely deliver high doses of ionizing radiation to small deep-seated target volumes. A similar noninvasive treatment modality for cardiac arrhythmias was tested here. This study used high-energy carbon ions for ablation of cardiac tissue in pigs. Doses of 25, 40, and 55 Gy were applied in forced-breath-hold to the atrioventricular junction, left atrial pulmonary vein junction, and freewall left ventricle of intact animals. Procedural success was tracked by (1.) in-beam positron-emission tomography (PET) imaging; (2.) intracardiac voltage mapping with visible lesion on ultrasound; (3.) lesion outcomes in pathohistolgy. High doses (40-55 Gy) caused slowing and interruption of cardiac impulse propagation. Target fibrosis was the main mediator of the ablation effect. In irradiated tissue, apoptosis was present after 3, but not 6 months. Our study shows feasibility to use high-energy ion beams for creation of cardiac lesions that chronically interrupt cardiac conduction.
Item Description:Gesehen am 18.06.2020
Physical Description:Online Resource
ISSN:2045-2322
DOI:10.1038/srep38895

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