Buchumschlag

Feasibility study on cardiac arrhythmia ablation using high-energy heavy ion beams

High-energy ion beams are successfully used in cancer therapy and precisely deliver high doses of ionizing radiation to small deep-seated target volumes. A similar noninvasive treatment modality for cardiac arrhythmias was tested here. This study used high-energy carbon ions for ablation of cardiac...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Lehmann, Helge Immo (VerfasserIn) , Graeff, Christian (VerfasserIn) , Simoniello, Palma (VerfasserIn) , Constantinescu, Anna (VerfasserIn) , Takami, Mitsuru (VerfasserIn) , Lugenbiel, Patrick (VerfasserIn) , Richter, Daniel (VerfasserIn) , Eichhorn, Anna (VerfasserIn) , Prall, Matthias (VerfasserIn) , Kaderka, Robert (VerfasserIn) , Fiedler, Fine (VerfasserIn) , Helmbrecht, Stephan (VerfasserIn) , Fournier, Claudia (VerfasserIn) , Erbeldinger, Nadine (VerfasserIn) , Rahm, Ann-Kathrin (VerfasserIn) , Rivinius, Rasmus (VerfasserIn) , Thomas, Dierk (VerfasserIn) , Katus, Hugo (VerfasserIn) , Johnson, Susan B. (VerfasserIn) , Parker, Kay D. (VerfasserIn) , Debus, Jürgen (VerfasserIn) , Asirvatham, Samuel J. (VerfasserIn) , Bert, Christoph (VerfasserIn) , Durante, Marco (VerfasserIn) , Packer, Douglas L. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 20 December 2016
In: Scientific reports
Year: 2016, Jahrgang: 6
ISSN:2045-2322
DOI:10.1038/srep38895
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/srep38895
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/srep38895
Volltext
Verfasserangaben:H. Immo Lehmann, Christian Graeff, Palma Simoniello, Anna Constantinescu, Mitsuru Takami, Patrick Lugenbiel, Daniel Richter, Anna Eichhorn, Matthias Prall, Robert Kaderka, Fine Fiedler, Stephan Helmbrecht, Claudia Fournier, Nadine Erbeldinger, Ann-Kathrin Rahm, Rasmus Rivinius, Dierk Thomas, Hugo A. Katus, Susan B. Johnson, Kay D. Parker, Jürgen Debus, Samuel J. Asirvatham, Christoph Bert, Marco Durante & Douglas L. Packer
Beschreibung
Zusammenfassung:High-energy ion beams are successfully used in cancer therapy and precisely deliver high doses of ionizing radiation to small deep-seated target volumes. A similar noninvasive treatment modality for cardiac arrhythmias was tested here. This study used high-energy carbon ions for ablation of cardiac tissue in pigs. Doses of 25, 40, and 55 Gy were applied in forced-breath-hold to the atrioventricular junction, left atrial pulmonary vein junction, and freewall left ventricle of intact animals. Procedural success was tracked by (1.) in-beam positron-emission tomography (PET) imaging; (2.) intracardiac voltage mapping with visible lesion on ultrasound; (3.) lesion outcomes in pathohistolgy. High doses (40-55 Gy) caused slowing and interruption of cardiac impulse propagation. Target fibrosis was the main mediator of the ablation effect. In irradiated tissue, apoptosis was present after 3, but not 6 months. Our study shows feasibility to use high-energy ion beams for creation of cardiac lesions that chronically interrupt cardiac conduction.
Beschreibung:Gesehen am 18.06.2020
Beschreibung:Online Resource
ISSN:2045-2322
DOI:10.1038/srep38895

Ähnliche Einträge