Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling

A redox relay was identified in mammalian cells where the H2O2-reactive protein peroxiredoxin-2 oxidizes the transcription factor STAT3, resulting in the formation of transcriptionally inactive disulfide-linked oligomers.

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Bibliographic Details
Main Authors:	Sobotta, Mirko Christoph (Author) , Liou, Willy (Author) , Stöcker, Sarah (Author) , Talwar, Deepti (Author) , Oehler, Michael (Author) , Ruppert, Thomas (Author) , Scharf, Annette N. D. (Author) , Dick, Tobias P. (Author)
Format:	Article (Journal)
Language:	English
Published:	2015
In:	Nature chemical biology Year: 2014, Volume: 11, Issue: 1, Pages: 64-70
ISSN:	1552-4469
DOI:	10.1038/nchembio.1695
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nchembio.1695 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nchembio.1695
Author Notes:	Mirko C. Sobotta, Willy Liou, Sarah Stöcker, Deepti Talwar, Michael Oehler, Thomas Ruppert, Annette N.D. Scharf & Tobias P. Dick

Description
Summary:	A redox relay was identified in mammalian cells where the H2O2-reactive protein peroxiredoxin-2 oxidizes the transcription factor STAT3, resulting in the formation of transcriptionally inactive disulfide-linked oligomers.
Item Description:	Published online: 24 november 2014 Gesehen am 18.06.2020 Im Titel ist "2" in H2O2 tiefgestellt
Physical Description:	Online Resource
ISSN:	1552-4469
DOI:	10.1038/nchembio.1695