Ti(OiPr)4-mediated multicomponent reactions involving triple additions to isonitrile carbon atoms
Double addition of Grignard reagents to isonitriles was achieved in the presence of stoichiometric amounts of [Ti(OiPr)4]. Functionalized isonitrile components were obtained in situ via lithiation of chiral and achiral 2-oxazolines, and the resulting amidomethyltitanium intermediate further reacted...
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| Main Authors: | , , , |
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| Format: | Article (Journal) Editorial |
| Language: | English |
| Published: |
September 27, 2016
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| In: |
Organic letters
Year: 2016, Volume: 18, Issue: 19, Pages: 5182-5185 |
| ISSN: | 1523-7052 |
| DOI: | 10.1021/acs.orglett.6b02746 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1021/acs.orglett.6b02746
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| Author Notes: | Francesco Foschi, Torsten Roth, Hubert Wadepohl, and Lutz H. Gade |
| Summary: | Double addition of Grignard reagents to isonitriles was achieved in the presence of stoichiometric amounts of [Ti(OiPr)4]. Functionalized isonitrile components were obtained in situ via lithiation of chiral and achiral 2-oxazolines, and the resulting amidomethyltitanium intermediate further reacted with a range of electrophiles. The established multicomponent procedure gave rise to highly substituted 2-aminomorpholines, acyclic diamino alcohols, and prenylated amino alcohols via straightforward synthetic protocols. |
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| Item Description: | Im Titel ist die Ziffer "4" tiefgestellt Gesehen am 19.06.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1523-7052 |
| DOI: | 10.1021/acs.orglett.6b02746 |