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FAP-specific PET signaling shows a moderately positive correlation with relative CBV and no correlation with ADC in 13 IDH wildtype glioblastomas

OBJECTIVES: Targeting Fibroblast Activation Protein (FAP) is a new approach for glioblastoma imaging. In a recent pilot study glioblastomas showed elevated tracer uptake with high intratumoral heterogeneity in projection on the corresponding T2w/FLAIR and contrast enhanced MRI lesions. In this study...

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Main Authors: Röhrich, Manuel (Author) , Floca, Ralf (Author) , Loi, Lisa (Author) , Adeberg, Sebastian (Author) , Windisch, Paul (Author) , Giesel, Frederik L. (Author) , Kratochwil, Clemens (Author) , Flechsig, Paul (Author) , Rathke, Hendrik (Author) , Lindner, Thomas (Author) , Loktev, Anastasia (Author) , Schlemmer, Heinz-Peter (Author) , Haberkorn, Uwe (Author) , Paech, Daniel (Author)
Format: Article (Journal)
Language:English
Published: 20 April 2020
In: European journal of radiology
Year: 2020, Volume: 127, Pages: 1-7
ISSN:1872-7727
DOI:10.1016/j.ejrad.2020.109021
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ejrad.2020.109021
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0720048X20302102
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Author Notes:Manuel Röhrich, Ralf Floca, Lisa Loi, Sebastian Adeberg, Paul Windisch, Frederik L. Giesel, Clemens Kratochwil, Paul Flechsig, Hendrik Rathke, Thomas Lindner, Anastasia Loktev, Heinz Peter Schlemmer, Uwe Haberkorn, Daniel Paech
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Summary:OBJECTIVES: Targeting Fibroblast Activation Protein (FAP) is a new approach for glioblastoma imaging. In a recent pilot study glioblastomas showed elevated tracer uptake with high intratumoral heterogeneity in projection on the corresponding T2w/FLAIR and contrast enhanced MRI lesions. In this study, we correlated FAP-specific signaling with apparent diffusion coefficient (ADC) and relative cerebral blood volume (rCBV) signals in MRI to further characterize the significance of FAP uptake. METHODS: Clinical PET/CT scans of 13 glioblastoma patients were performed post i. v. administration of 68Ga-labelled-FAP-specific tracer molecules. PET- and corresponding MRI-scans were co-registrated. 3d volumetric segmentations were performed of T2w/FLAIR lesions and contrast enhancing lesions within co-registrated MRI slides. Signal intensity values of FAP-specific PET signaling, ADC and rCBV were analyzed for their pixel wise correlation in each patient. Pooled estimates of the correlation coefficients were calculated by using the Fisher z-transformation. RESULTS: FAP-specific PET signals showed a moderately positive correlation with rCBV values which is more pronounced within the T2w/FLAIR lesion (pooled correlation 0,229) than in the contrast enhancing tumor region (pooled correlation 0.09). FAP-specific PET signals showed no correlation with ADC values. CONCLUSIONS: The moderately positive correlation of FAP-specific signals with rCBV values in MRI indicates that FAP-signaling is not independent from perfusion, but also does not only reflect intratumoral perfusion differences. The missing correlation of FAP-specific signals with ADC indicates that FAP-specific imaging does not reflect cell density, but the spot-like expression of FAP in glioblastomas. The clinical value of FAP-specific imaging needs further investigation.
Item Description:Gesehen am 23.06.2020
Physical Description:Online Resource
ISSN:1872-7727
DOI:10.1016/j.ejrad.2020.109021

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