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Oxidatively damaged DNA/RNA and 8-isoprostane levels are associated with the development of type 2 diabetes at older age: results from a large cohort study

OBJECTIVE Oxidative stress is believed to play an important role in the pathophysiology of type 2 diabetes, but the few cohort studies that have assessed the association of oxidative stress biomarkers with type 2 diabetes incidence were small and reported inconclusive results. - RESEARCH DESIGN AND...

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Main Authors: Schöttker, Ben (Author) , Xuan, Yang (Author) , Gao, Xin (Author) , Anusruti, Ankita (Author) , Brenner, Hermann (Author)
Format: Article (Journal)
Language:English
Published: 2020
In: Diabetes care
Year: 2020, Volume: 43, Issue: 1, Pages: 130-136
ISSN:1935-5548
DOI:10.2337/dc19-1379
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.2337/dc19-1379
Verlag, lizenzpflichtig, Volltext: https://care.diabetesjournals.org/content/43/1/130
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Author Notes:Ben Schöttker, Yang Xuan, Xīn Gào, Ankita Anusruti and Hermann Brenner
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Summary:OBJECTIVE Oxidative stress is believed to play an important role in the pathophysiology of type 2 diabetes, but the few cohort studies that have assessed the association of oxidative stress biomarkers with type 2 diabetes incidence were small and reported inconclusive results. - RESEARCH DESIGN AND METHODS We examined the associations of urinary oxidized guanine/guanosine (OxGua) levels (a biomarker of DNA/RNA oxidation) and urinary 8-isoprostane levels (a biomarker of lipid peroxidation) with type 2 diabetes incidence in 7,828 individuals initially without diabetes from a population-based German cohort study with 14 years of follow-up. Hazard ratios (HRs) (95% CIs) per 1 SD were obtained using multivariable-adjusted Cox proportional hazards regression models. - RESULTS In the total population, weak but statistically significant associations with type 2 diabetes incidence were observed for OxGua levels (HR [95% CI] per 1 SD 1.05 [1.01; 1.09]) and 8-isoprostane levels (1.04 [1.00; 1.09]). Stratified analyses showed that associations of both biomarkers with type 2 diabetes incidence were absent in the youngest age-group (50-59 years) and strongest in the oldest age-group (65-75 years) of the cohort, with HR of OxGua levels 1.14 (1.05; 1.23) per 1 SD and of 8-isoprostane levels 1.22 (1.02; 1.45) per 1 SD. - CONCLUSIONS These results from a large cohort study support suggestions that an imbalanced redox system contributes to the development of type 2 diabetes but suggest that this association becomes clinically apparent at older ages only, possibly as a result of reduced cellular repair capacity.
Item Description:Gesehen am 24.06.2020
Physical Description:Online Resource
ISSN:1935-5548
DOI:10.2337/dc19-1379

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