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The generation of carcinogenic etheno-DNA adducts in the liver of patients with nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD), in particular its more aggressive form nonalcoholic steatohepatitis (NASH) is increasingly observed as a cause of end stage liver disease and hepatocellular carcinoma (HCC). Reactive oxygen species (ROS) are an important factor in the pathogenesis of HCC. RO...

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Bibliographic Details
Main Authors: Linhart, Kirsten-Berit (Author) , Glassen, Katharina (Author) , Peccerella, Teresa (Author) , Waldherr, Rüdiger (Author) , Linhart, Heinz (Author) , Bartsch, Helmut (Author) , Seitz, Helmut K. (Author)
Format: Article (Journal)
Language:English
Published: 2015
In: Hepatobiliary surgery and nutrition
Year: 2015, Volume: 4, Issue: 2, Pages: 117-123
ISSN:2304-389X
Online Access:Verlag, lizenzpflichtig, Volltext: http://hbsn.amegroups.com/article/view/6106
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Author Notes:Kirsten-Berit Linhart, Katharina Glassen, Teresa Peccerella, Rüdiger Waldherr, Heinz Linhart, Helmut Bartsch, Helmut K. Seitz
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Summary:Nonalcoholic fatty liver disease (NAFLD), in particular its more aggressive form nonalcoholic steatohepatitis (NASH) is increasingly observed as a cause of end stage liver disease and hepatocellular carcinoma (HCC). Reactive oxygen species (ROS) are an important factor in the pathogenesis of HCC. ROS can react with polyunsaturated fatty acids derived from membrane phospholipids resulting in the production of reactive aldehydes as lipid oxidation (LPO) byproducts, such as 4-hydroxynonenal (4 HNE). 4 HNE can react with DNA to form mutagenic exocyclic etheno-DNA adducts. ROS is induced by inflammatory processes, but also by induction of cytochrome P450 2E1 (CYP2E1), as seen with chronic alcohol consumption.
Item Description:Gesehen am 24.06.2020
Physical Description:Online Resource
ISSN:2304-389X

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