Diffuse reflectance spectroscopy of human liver tumor specimens - towards a tissue differentiating optical biopsy needle using light emitting diodes
Significant numbers of liver biopsies fail to yield representative tissue samples. This study was conducted to evaluate the ability of LED-based diffuse reflectance spectroscopy to discriminate tumors from liver parenchyma. Ex vivo spectra were acquired from malignant lesions and liver parenchyma of...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
1 Mar 2018
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| In: |
Biomedical optics express
Year: 2018, Volume: 9, Issue: 3, Pages: 1069-1081 |
| ISSN: | 2156-7085 |
| DOI: | 10.1364/BOE.9.001069 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1364/BOE.9.001069 Verlag, lizenzpflichtig, Volltext: https://www.osapublishing.org/boe/abstract.cfm?uri=boe-9-3-1069 
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| Author Notes: | Alina Keller, Piotr Bialecki, Torsten Johannes Wilhelm and Marcus Klaus Vetter |
| Summary: | Significant numbers of liver biopsies fail to yield representative tissue samples. This study was conducted to evaluate the ability of LED-based diffuse reflectance spectroscopy to discriminate tumors from liver parenchyma. Ex vivo spectra were acquired from malignant lesions and liver parenchyma of 32 patients who underwent liver resection using a white light source and several LEDs. Integrated spectra of two combined LEDs with emission peaks at 470 nm and 515 nm were classified with 98.4% sensitivity and 99.2% specificity. The promising results could yield to a simple handheld and cost-efficient tool for real-time tissue differentiation implemented in a biopsy needle. |
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| Item Description: | Gesehen am 25.06.2020 |
| Physical Description: | Online Resource |
| ISSN: | 2156-7085 |
| DOI: | 10.1364/BOE.9.001069 |