TERRA and the state of the telomere
Transcription of telomeres generates long noncoding RNAs (lncRNAs) composed of telomeric repeat sequences (TERRA) that hybridize with telomeric DNA and are components of telomeric heterochromatin. This Perspective considers the physiological roles of TERRA in telomere homeostasis and proposes that T...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
4 November 2015
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| In: |
Nature structural & molecular biology
Year: 2015, Volume: 22, Issue: 11, Pages: 853-858 |
| ISSN: | 1545-9985 |
| DOI: | 10.1038/nsmb.3078 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nsmb.3078 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nsmb.3078 
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| Author Notes: | Karsten Rippe & Brian Luke |
| Summary: | Transcription of telomeres generates long noncoding RNAs (lncRNAs) composed of telomeric repeat sequences (TERRA) that hybridize with telomeric DNA and are components of telomeric heterochromatin. This Perspective considers the physiological roles of TERRA in telomere homeostasis and proposes that TERRA's functions are determined by the state of its telomere targets. |
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| Item Description: | Gesehen am 25.06.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1545-9985 |
| DOI: | 10.1038/nsmb.3078 |