Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells

Here, DNA damage is shown to occur as a direct consequence of inducing haematopoietic stem cells to exit quiescence in response to conditions of stress; in mice with mutations modelling those seen in Fanconi anaemia, this leads to a complete collapse of the haematopoietic system.

Bibliographic Details

Main Authors:	Walter, Dagmar (Author) , Lier, Amelie (Author) , Geiselhart, Anja (Author) , Thalheimer, Frederic (Author) , Huntscha, Sina (Author) , Sobotta, Mirko Christoph (Author) , Moehrle, Bettina (Author) , Brocks, David (Author) , Bayındır-Buchhalter, İrem (Author) , Kaschutnig, Paul Emanuel (Author) , Muedder, Katja (Author) , Klein, Corinna (Author) , Jauch, Anna (Author) , Schroeder, Timm (Author) , Geiger, Hartmut (Author) , Dick, Tobias P. (Author) , Holland-Letz, Tim (Author) , Schmezer, Peter (Author) , Lane, Steven W. (Author) , Rieger, Michael A. (Author) , Essers, Marieke (Author) , Williams, David A. (Author) , Trumpp, Andreas (Author) , Milsom, Michael (Author)
Format:	Article (Journal) Editorial
Language:	English
Published:	18 February 2015
In:	Nature Year: 2015, Volume: 520, Issue: 7548, Pages: 549-552
ISSN:	1476-4687
DOI:	10.1038/nature14131
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nature14131 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nature14131
Author Notes:	Dagmar Walter, Amelie Lier, Anja Geiselhart, Frederic B. Thalheimer, Sina Huntscha, Mirko C. Sobotta, Bettina Moehrle, David Brocks, Irem Bayindir, Paul Kaschutnig, Katja Muedder, Corinna Klein, Anna Jauch, Timm Schroeder, Hartmut Geiger, Tobias P. Dick, Tim Holland-Letz, Peter Schmezer, Steven W. Lane, Michael A. Rieger, Marieke A.G. Essers, David A. Williams, Andreas Trumpp & Michael D. Milsom